Centro de Investigação Interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz, Campus Universitário, Quinta da Granja, 2829-511 Monte de Caparica, Portugal.
Nutrients. 2022 Apr 10;14(8):1576. doi: 10.3390/nu14081576.
Cinnamon is a spice used in traditional cuisine that has been investigated due to hypoglycemic properties. The objective of this study was to investigate the effect of aqueous cinnamon extract on postprandial glycemia levels in type 2 diabetes mellitus (DM2) adults. This clinical trial enrolled 36 adults with DM2, randomly allocated in two groups: the control group ( = 18) took only an oral glucose tolerance test (OGTT) and the intervention group ( = 18) took OGTT immediately followed by aqueous cinnamon extract (6 g/100 mL) ingestion. Blood glucose levels were measured on fasting and after 30, 60, 90 and 120 min in both groups. The chemical analysis of the aqueous cinnamon extract included total phenols content determination and antioxidant activity assessment through FRAP and DPPH methods. The data reveal that aqueous cinnamon extract ingestion did not show a significant difference in the incremental area under the curve ( = 0.834), maximum glucose concentration ( = 0.527) and glucose concentration variation ( = 0.873) compared with the control group. Cinnamon extract possess a total phenol content of 1554.9 mg/L gallic acid equivalent and a strong antioxidant capacity, revealed by the DPPH (5125.0 µmol Trolox/L) and FRAP (3658.8 µmol Trolox/L) tests. Aqueous cinnamon extract did not significantly influence postprandial glucose response in diabetic patients during an OGTT.
肉桂是一种在传统烹饪中使用的香料，由于其降血糖的特性而受到研究。本研究的目的是研究水肉桂提取物对 2 型糖尿病（DM2）成人餐后血糖水平的影响。这项临床试验招募了 36 名 2 型糖尿病患者，随机分为两组：对照组（n = 18）仅进行口服葡萄糖耐量试验（OGTT），干预组（n = 18）在 OGTT 后立即服用水肉桂提取物（6 克/100 毫升）。两组均在空腹和 30、60、90 和 120 分钟时测量血糖水平。水肉桂提取物的化学分析包括总酚含量的测定和通过 FRAP 和 DPPH 方法评估抗氧化活性。数据显示，与对照组相比，水肉桂提取物的摄入并没有在曲线下面积增量（= 0.834）、最大葡萄糖浓度（= 0.527）和葡萄糖浓度变化（= 0.873）方面显示出显著差异。肉桂提取物的总酚含量为 1554.9 mg/L 没食子酸当量，具有很强的抗氧化能力，DPPH（5125.0 µmol Trolox/L）和 FRAP（3658.8 µmol Trolox/L）试验均显示了这一点。水肉桂提取物在 OGTT 期间对糖尿病患者的餐后血糖反应没有显著影响。
