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用于预测II/III期结直肠癌患者预后的胶原特征的开发与验证

Development and validation of a collagen signature to predict the prognosis of patients with stage II/III colorectal cancer.

作者信息

Dong Shumin, Wang Huaiming, Ji Hongli, Hu Yaowen, Zhao Shuhan, Yan Botao, Wang Guangxing, Lin Zexi, Zhu Weifeng, Lu Jianping, Cheng Jiaxin, Wu Zhida, Zhu Qiong, Zhuo Shuangmu, Chen Gang, Yan Jun

机构信息

Department of General Surgery & Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China.

School of Science, Jimei University, Xiamen 361021, China.

出版信息

iScience. 2023 Apr 25;26(5):106746. doi: 10.1016/j.isci.2023.106746. eCollection 2023 May 19.

DOI:10.1016/j.isci.2023.106746
PMID:37216096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10192940/
Abstract

The tumor, nodes and metastasis (TNM) classification system provides useful but incomplete prognostic information and lacks the assessment of the tumor microenvironment (TME). Collagen, the main component of the TME extracellular matrix, plays a nonnegligible role in tumor invasion and metastasis. In this cohort study, we aimed to develop and validate a TME collagen signature (CS) for prognostic prediction of stage II/III colorectal cancer (CRC) and to compare the prognostic values of "TNM stage + CS" with that of TNM stage alone. Results indicated that the CS was an independent prognostic risk factor for stage II/III CRC (hazard ratio: 2.939, 95% CI: 2.180-3.962, p < 0.0001), and the integration of the TNM stage and CS had a better prognostic value than that of the TNM stage alone (AUC = 0.772, AUC  = 0.687, p < 0.0001). This study provided an application of "seed and soil" strategy for prognosis prediction and individualized therapy.

摘要

肿瘤、淋巴结和转移（TNM）分类系统提供了有用但不完整的预后信息，且缺乏对肿瘤微环境（TME）的评估。胶原蛋白是TME细胞外基质的主要成分，在肿瘤侵袭和转移中起着不可忽视的作用。在这项队列研究中，我们旨在开发并验证一种用于预测II/III期结直肠癌（CRC）预后的TME胶原蛋白特征（CS），并比较“TNM分期+CS”与单独TNM分期的预后价值。结果表明，CS是II/III期CRC的独立预后危险因素（风险比：2.939，95%置信区间：2.180-3.962，p<0.0001），且TNM分期与CS相结合的预后价值优于单独的TNM分期（曲线下面积=0.772，曲线下面积=0.687，p<0.0001）。本研究为预后预测和个体化治疗提供了“种子与土壤”策略的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de04/10192940/4336b691c04a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de04/10192940/c8a0a3b78520/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de04/10192940/ac6c16a24068/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de04/10192940/9ca9a0f8be87/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de04/10192940/b78fd8f23c38/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de04/10192940/4336b691c04a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de04/10192940/c8a0a3b78520/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de04/10192940/ac6c16a24068/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de04/10192940/9ca9a0f8be87/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de04/10192940/b78fd8f23c38/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de04/10192940/4336b691c04a/gr4.jpg

相似文献

[1]
Development and validation of a collagen signature to predict the prognosis of patients with stage II/III colorectal cancer.

iScience. 2023-4-25

[2]
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Cancer Med. 2023-4

[3]
Association of Tumor-Associated Collagen Signature With Prognosis and Adjuvant Chemotherapy Benefits in Patients With Gastric Cancer.

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[4]
CINSARC signature outperforms gold-standard TNM staging and consensus molecular subtypes for clinical outcome in stage II-III colorectal carcinoma.

Mod Pathol. 2022-12

[5]
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[6]
A Prediction Model for Tumor Recurrence in Stage II-III Colorectal Cancer Patients: From a Machine Learning Model to Genomic Profiling.

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[7]
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[8]
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[9]
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World J Surg Oncol. 2021-4-18

[10]
Prognostic models based on postoperative circulating tumor cells can predict poor tumor recurrence-free survival in patients with stage II-III colorectal cancer.

J Cancer. 2019-7-25

引用本文的文献

[1]
Collagen disorder architecture features are associated with clinical, molecular, genetic factors and survival outcomes in colon cancer.

NPJ Precis Oncol. 2025-8-28

[2]
Advances in Molecular Function and Recombinant Expression of Human Collagen.

Pharmaceuticals (Basel). 2025-3-18

[3]
High levels of fibrotic tumor components are associated with recurrence and intratumoral immune status in advanced colorectal cancer patients.

Sci Rep. 2024-12-28

[4]
The relationship between the collagen score at the anastomotic site of esophageal squamous cell carcinoma and anastomotic leakage.

J Thorac Dis. 2024-7-30

本文引用的文献

[1]
Collagen score in the tumor microenvironment predicts the prognosis of rectal cancer patients after neoadjuvant chemoradiotherapy.

Radiother Oncol. 2022-2

[2]
Computer-assisted quantification of tumor-associated collagen signatures to improve the prognosis prediction of breast cancer.

BMC Med. 2021-11-18

[3]
Extracellular Matrix Biomarkers in Colorectal Cancer.

Int J Mol Sci. 2021-8-25

[4]
Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance.

Nat Commun. 2021-6-23

[5]
Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism.

Gut. 2022-1

[6]
Association of the Collagen Signature in the Tumor Microenvironment With Recurrence and Survival of Patients With T4N0M0 Colon Cancer.

Dis Colon Rectum. 2021-5

[7]
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.

CA Cancer J Clin. 2021-5

[8]
Cancer Statistics, 2021.

CA Cancer J Clin. 2021-1

[9]
Predicting postoperative peritoneal metastasis in gastric cancer with serosal invasion using a collagen nomogram.

Nat Commun. 2021-1-8

[10]
Concepts of extracellular matrix remodelling in tumour progression and metastasis.

Nat Commun. 2020-10-9

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