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高盐饮食肥胖-T2DM 小鼠的小肠微生物群落组成发生改变。

Small intestinal microbiota composition altered in obesity-T2DM mice with high salt fed.

机构信息

Xinjiang Key Laboratory of Special Species Conservation and Regulatory Biology, College of Life Science, Xinjiang Normal University, Urumqi, China.

Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

出版信息

Sci Rep. 2023 May 22;13(1):8256. doi: 10.1038/s41598-023-33909-2.

DOI:10.1038/s41598-023-33909-2
PMID:37217529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10203271/
Abstract

Obesity has become a global concern because of increasing the risk of many diseases. Alterations in human gut microbiota have been proven to be associated with obesity, yet the mechanism of how the microbiota are altered by high salt diet (HSD) remains obscure. In this study, the changes of Small Intestinal Microbiota (SIM) in obesity-T2DM mice were investigated. High-throughput sequencing was applied for the jejunum microbiota analysis. Results revealed that high salt intake (HS) could suppress the body weight (B.W.) in some extent. In addition, significant T2DM pathological features were revealed in high salt-high food diet (HS-HFD) group, despite of relatively lower food intake. High-throughput sequencing analysis indicated that the F/B ratio in HS intake groups increased significantly (P < 0.001), whereas beneficial bacteria, such as lactic acid or short chain fatty acid producing bacteria, were significantly decreased in HS-HFD group (P < 0.01 or P < 0.05). Furthermore, Halorubrum luteum were observed in small intestine for the first time. Above results preliminary suggested that in obesity-T2DM mice, high dietary salt could aggravate the imbalance of composition of SIM to unhealthy direction.

摘要

肥胖已经成为一个全球性的问题，因为它会增加许多疾病的风险。人类肠道微生物群的改变已被证明与肥胖有关，但高盐饮食（HSD）如何改变微生物群的机制仍不清楚。在这项研究中，研究了肥胖-T2DM 小鼠的小肠微生物群（SIM）的变化。采用高通量测序技术对空肠微生物群进行了分析。结果表明，高盐摄入（HS）在一定程度上可以抑制体重（B.W.）。此外，尽管食物摄入量相对较低，但在高盐高食物饮食（HS-HFD）组中发现了明显的 T2DM 病理特征。高通量测序分析表明，HS 摄入组的 F/B 比值显著增加（P<0.001），而 HS-HFD 组中有益菌（如产乳酸或短链脂肪酸的细菌）显著减少（P<0.01 或 P<0.05）。此外，首次在小肠中观察到 Halorubrum luteum。上述结果初步表明，在肥胖-T2DM 小鼠中，高膳食盐可加重 SIM 组成的失衡向不健康的方向发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b4f/10203271/b8f94d923f2d/41598_2023_33909_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b4f/10203271/5fd367443294/41598_2023_33909_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b4f/10203271/3eb04732ba34/41598_2023_33909_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b4f/10203271/af51409c5f79/41598_2023_33909_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b4f/10203271/554c7553a9c4/41598_2023_33909_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b4f/10203271/a06253d8291a/41598_2023_33909_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b4f/10203271/408c30533093/41598_2023_33909_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b4f/10203271/b8f94d923f2d/41598_2023_33909_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b4f/10203271/5fd367443294/41598_2023_33909_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b4f/10203271/3eb04732ba34/41598_2023_33909_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b4f/10203271/af51409c5f79/41598_2023_33909_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b4f/10203271/554c7553a9c4/41598_2023_33909_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b4f/10203271/a06253d8291a/41598_2023_33909_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b4f/10203271/408c30533093/41598_2023_33909_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b4f/10203271/b8f94d923f2d/41598_2023_33909_Fig7_HTML.jpg

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3
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4
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