Schmidt S Y, Peisch R D
Invest Ophthalmol Vis Sci. 1986 Jul;27(7):1063-7.
Melanin concentrations were analyzed in the pigment epithelium of 61 postmortem normal human eyes from donors 14-97 yr of age. The content of soluble melanin in the pigment epithelium declined with age from the highest values of 95 micrograms/mg in the 14-50 yr age group to the lowest values of 22 micrograms/mg dry weight in the over 70 yr age group. In 16 of these eyes, regional measurements revealed that melanin concentrations were lowest in the macula-perimacular area (a region 5-8 mm in diameter centered on the fovea), were higher in the mid-periphery, and were highest in the far periphery. In the macular region, melanin concentrations were similarly low at all ages, whereas, in the mid- and far-peripheral regions, melanin concentrations decreased with age. These studies demonstrate age-related reductions and regional variations in melanin concentrations in the pigment epithelium of postmortem normal human eyes, and establish a baseline for future comparison with donor eyes from patients with hereditary retinal degenerations.
对61只来自14至97岁供体的正常人类死后眼睛的色素上皮中的黑色素浓度进行了分析。色素上皮中可溶性黑色素的含量随年龄下降，从14至50岁年龄组的最高值95微克/毫克降至70岁以上年龄组的最低值22微克/毫克干重。在其中16只眼中，区域测量显示，黑色素浓度在黄斑-黄斑周围区域（以中央凹为中心、直径5至8毫米的区域）最低，在中周边区域较高，在远周边区域最高。在黄斑区域，所有年龄段的黑色素浓度都同样较低，而在中周边和远周边区域，黑色素浓度随年龄下降。这些研究证明了正常人类死后眼睛色素上皮中黑色素浓度与年龄相关的降低和区域差异，并为未来与遗传性视网膜变性患者的供体眼睛进行比较建立了基线。
