Masoudi-Khoram Nastaran, Soheilifar Mohammad Hasan, Ghorbanifar Shima, Nobari Sima, Hakimi Maryam, Hassani Mahmoud
Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.
Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran.
Crit Rev Oncol Hematol. 2023 May;185:103967. doi: 10.1016/j.critrevonc.2023.103967. Epub 2023 Mar 23.
Cancer-associated fibroblasts (CAFs) are the prominent stromal cell population in the tumor microenvironment (TME), which play an indispensable role in cancer progression and response to therapy. CAFs provide communication between tumor cells and surrounding cells by secreting soluble biomolecules and extracellular vesicles (EVs). Exosomes are small membrane-bound EVs that contain various cargos, including growth factors, non-coding RNAs (ncRNAs), cytokines, and chemokines. These biomolecules can be transferred between cells within the TME and alter the behavior of recipient cells. Some studies have shown that exosomes secreted by CAFs contribute to resistance to chemotherapy and radiotherapy. This review focuses on CAF-derived exosomes in different types of tumors, with emphasis on resistance to chemotherapy and radiotherapy.
癌症相关成纤维细胞（CAFs）是肿瘤微环境（TME）中主要的基质细胞群体，在癌症进展和对治疗的反应中发挥着不可或缺的作用。CAFs通过分泌可溶性生物分子和细胞外囊泡（EVs）在肿瘤细胞与周围细胞之间提供通讯。外泌体是小的膜结合EVs，包含各种货物，包括生长因子、非编码RNA（ncRNAs）、细胞因子和趋化因子。这些生物分子可在TME内的细胞之间转移并改变受体细胞的行为。一些研究表明，CAFs分泌的外泌体有助于化疗和放疗耐药。本综述重点关注不同类型肿瘤中CAF衍生的外泌体，重点是对化疗和放疗的耐药性。
