多头蜈蚣 A 和 B，从筋骨草中分离得到的新型抗凝成分。
Polycephalums A and B, New Anticoagulant Constituents Isolated from Clinopodium polycephalum.
机构信息
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, P. R. China.
Chongqing Institute for Food and Drug Control, NMPA Key Laboratory for Quality Monitoring of Narcotic Drugs and Psychotropic Substances, Chongqing, 401121, P. R. China.
出版信息
Chem Biodivers. 2023 Jun;20(6):e202300448. doi: 10.1002/cbdv.202300448. Epub 2023 Jun 6.
Two previously undescribed compounds (1 and 2) were isolated from Clinopodium polycephalum, a medicinal plant distributed in southwestern and eastern China. Their structures were elucidated using MS analyses and extensive 2D-homo and heteronuclear NMR data interpretations. Both compounds 1 and 2 could significantly shorten APTT and PT, and their procoagulant effect was comparable to that of positive drugs. At the same time, compound 2 had certain antioxidant activity (IC value of 2.25±0.05 μM in ABTS assay).
从分布在中国西南部和东部的药用植物荆芥中分离得到两种以前未描述的化合物（1 和 2）。通过 MS 分析和广泛的 2D 同核和异核 NMR 数据解释确定了它们的结构。化合物 1 和 2 均可显著缩短 APTT 和 PT，其促凝作用与阳性药物相当。同时，化合物 2 具有一定的抗氧化活性（ABTS 测定中 IC 值为 2.25±0.05μM）。
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