Cancer Imaging Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Tomography. 2023 Apr 30;9(3):931-941. doi: 10.3390/tomography9030076.
Genetically engineered mouse models (GEMMs) and patient-derived xenograft mouse models (PDXs) can recapitulate important biological features of cancer. They are often part of precision medicine studies in a co-clinical setting, in which therapeutic investigations are conducted in patients and in parallel (or sequentially) in cohorts of GEMMs or PDXs. Employing radiology-based quantitative imaging in these studies allows in vivo assessment of disease response in real time, providing an important opportunity to bridge precision medicine from the bench to the bedside. The Co-Clinical Imaging Research Resource Program (CIRP) of the National Cancer Institute focuses on the optimization of quantitative imaging methods to improve co-clinical trials. The CIRP supports 10 different co-clinical trial projects, spanning diverse tumor types, therapeutic interventions, and imaging modalities. Each CIRP project is tasked to deliver a unique web resource to support the cancer community with the necessary methods and tools to conduct co-clinical quantitative imaging studies. This review provides an update of the CIRP web resources, network consensus, technology advances, and a perspective on the future of the CIRP. The presentations in this special issue of Tomography were contributed by the CIRP working groups, teams, and associate members.
基因工程小鼠模型（GEMM）和患者来源异种移植小鼠模型（PDX）可以重现癌症的重要生物学特征。它们通常是临床前精准医学研究的一部分，其中治疗研究在患者中进行，并与 GEMM 或 PDX 队列中的平行（或顺序）进行。在这些研究中使用基于放射学的定量成像可以实时评估疾病反应，为将精准医学从实验室转移到临床提供了一个重要的机会。美国国立癌症研究所的临床前成像研究资源计划（CIRP）专注于优化定量成像方法，以改善临床前试验。CIRP 支持 10 个不同的临床前试验项目，涵盖了多种肿瘤类型、治疗干预措施和成像方式。每个 CIRP 项目的任务是提供一个独特的网络资源，为癌症社区提供必要的方法和工具，以进行临床前定量成像研究。本文综述了 CIRP 的网络资源、网络共识、技术进展以及对 CIRP 未来的展望。本期特刊中的演讲来自 CIRP 的工作组、团队和准成员。
