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抑郁反刍和特质焦虑在成年志愿者中,中介了儿童期受虐对成年后抑郁症状的影响。

Depressive rumination and trait anxiety mediate the effects of childhood victimization on adulthood depressive symptoms in adult volunteers.

机构信息

Department of Psychiatry, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.

出版信息

PLoS One. 2023 May 23;18(5):e0286126. doi: 10.1371/journal.pone.0286126. eCollection 2023.

Abstract

BACKGROUND

Prior studies have reported that childhood victimization experiences substantially augment the risk of depression and suicide in adulthood. Several of our previous studies suggested that childhood experiences of victimization interact with the quality of parenting experienced in childhood, childhood experiences of abuse, neuroticism, and other factors to influence depressive symptoms in adulthood. In this study, it was hypothesized that "childhood victimization" worsens "trait anxiety" and "depressive rumination", and that "trait anxiety" and "depressive rumination" are mediators that worsen "depressive symptoms in adulthood".

SUBJECTS AND METHODS

The following self-administered questionnaires were completed by 576 adult volunteers: Patient Health Questionnaire-9, State-Trait Anxiety Inventory form Y, Ruminative Responses Scale, and Childhood Victimization Rating Scale. Statistical analyses were performed by Pearson correlation coefficient analysis, t-test, multiple regression analysis, path analysis, and covariance structure analysis.

RESULTS

Path analysis demonstrated that the direct effect was statistically significant for the paths from childhood victimization to trait anxiety, depressive rumination, and depressive symptom severity. Moreover, the indirect effect of childhood victimization on depressive rumination mediated by trait anxiety was statistically significant. The indirect effects of childhood victimization on depressive symptom severity mediated by trait anxiety and depressive rumination were statistically significant. Furthermore, the indirect effect of childhood victimization on depressive symptom severity mediated by both trait anxiety and depressive rumination was statistically significant.

CONCLUSIONS

We found that childhood victimization directly and adversely influenced each of the above factors, and indirectly worsened adulthood depressive symptoms with trait anxiety and depressive ruminations as mediating factors. The present study is the first to clarify these mediation effects. Therefore, the results of this study suggest the importance of preventing childhood victimization and the importance of identifying and addressing childhood victimization in patients with clinical depression.

摘要

背景

先前的研究报告表明,儿童期受虐经历会大大增加成年后患抑郁症和自杀的风险。我们之前的几项研究表明,儿童期受虐经历与童年期经历的父母教养质量、虐待经历、神经质和其他因素相互作用,影响成年后的抑郁症状。在这项研究中,我们假设“儿童期受虐”会加重“特质焦虑”和“抑郁反刍”,而“特质焦虑”和“抑郁反刍”是加重“成年期抑郁症状”的中介因素。

对象和方法

576 名成年志愿者完成了以下自我管理问卷:患者健康问卷-9、状态特质焦虑量表 Y、反刍反应量表和儿童期受虐评定量表。采用 Pearson 相关系数分析、t 检验、多元回归分析、路径分析和协方差结构分析进行统计学分析。

结果

路径分析表明,从儿童期受虐到特质焦虑、抑郁反刍和抑郁症状严重程度的路径具有统计学意义的直接效应。此外,特质焦虑中介的儿童期受虐对抑郁反刍的间接效应具有统计学意义。特质焦虑和抑郁反刍中介的儿童期受虐对抑郁症状严重程度的间接效应具有统计学意义。此外,特质焦虑和抑郁反刍共同中介的儿童期受虐对抑郁症状严重程度的间接效应具有统计学意义。

结论

我们发现,儿童期受虐直接且不利地影响了上述所有因素,并且通过特质焦虑和抑郁反刍作为中介因素间接加重了成年后的抑郁症状。本研究首次阐明了这些中介效应。因此,这项研究的结果表明了预防儿童期受虐的重要性,以及在患有临床抑郁症的患者中识别和解决儿童期受虐问题的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ca0/10204941/09013f2d1565/pone.0286126.g001.jpg

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