O'Caoimh Rónán, Molloy D William
Centre for Gerontology and Rehabilitation, University College Cork, St Finbarr's Hospital, Cork City, Ireland.
Department of Geriatric Medicine, Mercy University Hospital, Cork City, Ireland.
J Alzheimers Dis Rep. 2023 Apr 20;7(1):299-306. doi: 10.3233/ADR220117. eCollection 2023.
Short cognitive screening instruments (CSI) are required to identify cognitive impairment in busy outpatient clinics. While the Six Item Cognitive Impairment Test (6CIT) is commonly used, its accuracy in those with mild cognitive impairment (MCI) and subjective cognitive decline (SCD) and against more widely-used CSIs is less well established.
To examine the diagnostic accuracy of the 6CIT against the Montreal Cognitive Assessment (MoCA) and Quick Mild Cognitive Impairment (Q) screen across the cognitive spectrum in a memory clinic population.
In total, 142 paired assessments were available (21 with SCD, 32 MCI, and 89 with dementia). Consecutive patients underwent a comprehensive assessment and were screened using the 6CIT, Q, and MoCA. Accuracy was determined from the area under receiver operating characteristic curves (AUC).
The median age of patients was 76 (±11) years; 68% were female. The median 6CIT score was 10/28 (±14). The 6CIT was strongly, negatively, and statistically significantly correlated with the Qi ( = -0.84) and MoCA ( = -0.86). The 6CIT had good accuracy for separating cognitive impairment (MCI or dementia) from SCD, (AUC:0.88; 0.82-0.94), similar to the MoCA (AUC:0.92; 0.87-0.97, = 0.308), but statistically lower than the Q (AUC:0.96; 0.94-0.99, = 0.01). The 6CIT was faster to administer, median time 2.05 minutes versus 4.38 and 9.5 for the Q and MoCA, respectively.
While the Q was more accurate than the 6CIT, the shorter administration time of the 6CIT, suggests it may be useful when assessing or monitoring cognitive impairment in busy memory clinics, though larger samples are required to evaluate.
在繁忙的门诊诊所中，需要使用简短的认知筛查工具（CSI）来识别认知障碍。虽然六项认知障碍测试（6CIT）被广泛使用，但其在轻度认知障碍（MCI）和主观认知下降（SCD）患者中的准确性，以及与更广泛使用的CSI相比的准确性，尚不明确。
在记忆门诊人群中， across the cognitive spectrum，研究6CIT相对于蒙特利尔认知评估（MoCA）和快速轻度认知障碍（Q）筛查的诊断准确性。
总共获得了142对评估结果（21例SCD患者、32例MCI患者和89例痴呆患者）。连续的患者接受了全面评估，并使用6CIT、Q和MoCA进行筛查。根据受试者操作特征曲线（AUC）下的面积确定准确性。
患者的中位年龄为76（±11）岁；68%为女性。6CIT的中位得分为10/28（±14）。6CIT与Qi（=-0.84）和MoCA（=-0.86）呈强负相关且具有统计学意义。6CIT在区分认知障碍（MCI或痴呆）与SCD方面具有良好的准确性（AUC：0.88；0.82-0.94），与MoCA相似（AUC：0.92；0.87-0.97，=0.308），但在统计学上低于Q（AUC：0.96；0.94-0.99，=0.01）。6CIT的施测速度更快，中位时间为2.05分钟，而Q和MoCA分别为4.38分钟和9.5分钟。
虽然Q比6CIT更准确，但6CIT的施测时间更短，这表明它在繁忙的记忆诊所评估或监测认知障碍时可能有用，不过需要更大的样本进行评估。
“across the cognitive spectrum”原文表述不太准确完整，翻译可能存在一定局限性。
