Department of Histopathology, KK Women's and Children's Hospital, Singapore
Department of Histopathology, KK Women's and Children's Hospital, Singapore.
BMJ Case Rep. 2023 May 23;16(5):e254190. doi: 10.1136/bcr-2022-254190.
Primary signet-ring cell carcinoma of the uterus is rare and requires exclusion of possible metastatic tumour to the uterus. We report a case of a woman in her 70s who underwent hysteroscopy and a polypectomy for a polyp arising from the uterine wall. On histological examination, malignant cells with signet-ring cell morphology were found within the fragments of endometrial tissue. Immunohistochemical studies indicated a metastatic adenocarcinoma possibly from the gastrointestinal tract. Additional radiological investigations revealed a possible primary gastric tumour, which was further confirmed on subsequent biopsies. This case illustrates that gastric carcinomas can rarely metastasise to the endometrium and highlights the importance of clinical correlation in arriving at the final diagnosis.
子宫原发性印戒细胞癌罕见，需要排除可能转移到子宫的肿瘤。我们报告了一例 70 多岁的女性，因子宫壁息肉而行宫腔镜检查和息肉切除术。组织学检查发现，子宫内膜组织碎片中有具有印戒细胞形态的恶性细胞。免疫组织化学研究表明，转移性腺癌可能来自胃肠道。进一步的影像学检查发现可能存在原发性胃肿瘤，随后的活检进一步证实了这一点。本例说明胃腺癌很少转移到子宫内膜，并强调了临床相关性在最终诊断中的重要性。
