中国大陆一例由新型耐药且Erg11基因发生Y132F突变引起的念珠菌血症病例。
A Candidemia Case Caused by a Novel Drug-Resistant with the Y132F Mutation in Erg11 in Mainland China.
作者信息
Xu Zhaoxia, Zhang Lei, Han Ran, Ding Chengwei, Shou Haochang, Duan Xueguang, Zhang Shengwei
机构信息
Department of Clinical Laboratory, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, People's Republic of China.
出版信息
Infect Drug Resist. 2023 May 18;16:3065-3072. doi: 10.2147/IDR.S409708. eCollection 2023.
BACKGROUND
is a pathogen first found in external ear canal, becoming a major threat to global health. Here, we describe a candidemia case caused by a novel drug-resistant strain.
CASE PRESENTATION
An 80-year-old patient, with multiple serious medical conditions, was suffered from candidemia caused by , died 9 days after admission in our hospital. Phylogenetic analysis indicates that this isolate (designated BJCA003) belongs to the South Asian clade, carries the Y132F mutation in the protein Erg11. And antibiotic susceptibility test indicated that BJCA003 is resistant to fluconazole and amphotericin B, not susceptible to caspofungin. In addition, this strain has multiple colony and cellular morphologies under different culture conditions.
CONCLUSION
Strain BJCA003 is a novel drug resistant strain in mainland China, the Y132F mutation in Erg11 may attribute to fluconazole-resistance, alarming that we still face more challenges about
背景
是一种首次在外耳道发现的病原体，对全球健康构成重大威胁。在此，我们描述一例由新型耐药菌株引起的念珠菌血症病例。
病例介绍
一名80岁患者，患有多种严重疾病，因念珠菌血症入院，在我院住院9天后死亡。系统发育分析表明，该分离株（命名为BJCA003）属于南亚分支，在蛋白质Erg11中携带Y132F突变。药敏试验表明，BJCA003对氟康唑和两性霉素B耐药，对卡泊芬净不敏感。此外，该菌株在不同培养条件下具有多种菌落和细胞形态。
结论
菌株BJCA003是中国大陆一种新型耐药菌株，Erg11中的Y132F突变可能导致氟康唑耐药，警示我们在……方面仍面临更多挑战。
（注：原文中部分关键信息缺失，如具体病原体名称等，翻译可能存在一定局限性。）
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