Rasaei Nakisa, Shams Mesbah, Kamali-Sarvestani Eskandar, Nazarinia Mohammad Ali
Internal Medicine Ward, Shiraz University of Medical Sciences, Shiraz, IR Iran.
Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran.
Iran Red Crescent Med J. 2015 Dec 5;17(12):e17298. doi: 10.5812/ircmj.17298. eCollection 2015 Dec.
Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease caused by immune system-mediated tissue damage. Autoimmune thyroiditis (AT) is an organ-specific disease associated with production of a variety of antibodies such as antinuclear antibodies, anti-double-stranded DNA, anti-Ro antibodies and anti-cardiolipin antibodies.
The aim of this study was to evaluate the prevalence of thyroid dysfunction and thyroid auto-antibodies in patients with SLE and its relation to SLE disease and other autoantibodies.
This was a case-control study. The study included a total of 88 patients with SLE and 88 age- and sex-matched healthy volunteers as control group. Two study groups were compared regarding thyroid function test, antinuclear antibody (ANA), antibodies to double-stranded DNA (dsDNA), anti- thyroglobulin antibody (anti-Tg), and anti-thyroid peroxidase (anti-TPO) antibody.
The mean age of SLE patients and controls were 32.16 ± 9.19 and 32.48 ± 9.47 years, respectively (P = 0.821). Patients had significantly higher prevalence (43.2% vs. 23.9%; P = 0.015) and titers (221.8 ± 570.5 vs. 78.2 ± 277.2; P = 0.036) of antibodies to Tg compared to controls. The patients had significantly lower titers of T3 compared to controls (125.2 ± 35.6 vs. 136.2 ± 26.5; P = 0.021). The titers of T4, TSH and anti-TPO antibody did not differ significantly between the two study groups.
Thyroid dysfunction was not higher in SLE patients compared to healthy individuals. However, anti-Tg antibodies were higher in SLE patients. It has not yet been established that thyroid function tests should be performed routinely in SLE patients.
系统性红斑狼疮（SLE）是一种由免疫系统介导的组织损伤引起的多系统自身免疫性疾病。自身免疫性甲状腺炎（AT）是一种器官特异性疾病，与多种抗体的产生有关，如抗核抗体、抗双链DNA抗体、抗Ro抗体和抗心磷脂抗体。
本研究旨在评估SLE患者甲状腺功能障碍和甲状腺自身抗体的患病率及其与SLE疾病和其他自身抗体的关系。
这是一项病例对照研究。该研究共纳入88例SLE患者和88例年龄及性别匹配的健康志愿者作为对照组。比较了两组在甲状腺功能检查、抗核抗体（ANA）、双链DNA（dsDNA）抗体、抗甲状腺球蛋白抗体（抗-Tg）和抗甲状腺过氧化物酶（抗-TPO）抗体方面的情况。
SLE患者和对照组的平均年龄分别为32.16±9.19岁和32.48±9.47岁（P = 0.821）。与对照组相比，患者抗-Tg抗体的患病率（43.2%对23.9%；P = 0.015）和滴度（221.8±570.5对78.2±277.2；P = 0.036）显著更高。与对照组相比，患者的T3滴度显著更低（125.2±35.6对136.2±26.5；P = 0.021）。两组研究对象的T4、促甲状腺激素（TSH）和抗-TPO抗体滴度无显著差异。
与健康个体相比，SLE患者的甲状腺功能障碍并不更高。然而，SLE患者的抗-Tg抗体更高。尚未确定是否应在SLE患者中常规进行甲状腺功能检查。
