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过去 20 年口腔白斑的恶性转化率:系统评价和荟萃分析。

Malignant transformation rate of oral leukoplakia in the past 20 years: A systematic review and meta-analysis.

机构信息

School of Stomatology, Jinan University, Guangzhou, China.

Department of Stomatology, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.

出版信息

J Oral Pathol Med. 2023 Sep;52(8):691-700. doi: 10.1111/jop.13440. Epub 2023 May 24.

Abstract

BACKGROUND

This meta-analysis aimed to assess the rate of malignant transformation (MT) of oral leukoplakia (OL) and to study potential risk factors for the MT of OL into oral squamous cell carcinoma (OSCC).

METHOD

We performed a bibliographic search on nine electronic databases, including PubMed, MEDLINE, and Wanfang Data, for data on the MT rate of OL. Possible risk factors were calculated using Comprehensive Meta-Analysis and Open Meta [Analyst] software.

RESULTS

The pooled proportion of OL MT for the total population described in the 26 selected studies was 7.20% (95% confidence interval: 5.40-9.10%). Nonhomogeneous type lesions, higher grades of dysplasia, the location of the lesion (tongue and multifocal), and female sex had significant effects on the MT of OL.

CONCLUSION

OL tended to develop into OSCC (7.2%), and those with significant MT risk factors should be subjected to regular follow-up and observation. However, we require large-scale prospective studies to validate these results, together with unified clinicopathological diagnostic criteria, standardized risk factor recording/assessment methods, and long-term follow-up guidelines.

摘要

背景

本荟萃分析旨在评估口腔白斑(OL)恶变(MT)的发生率,并研究 OL 向口腔鳞状细胞癌(OSCC)MT 的潜在危险因素。

方法

我们在九个电子数据库(包括 PubMed、MEDLINE 和万方数据)中进行了文献检索,以获取 OL MT 发生率的数据。使用 Comprehensive Meta-Analysis 和 Open Meta [Analyst] 软件计算可能的危险因素。

结果

26 项选定研究中总体人群 OL MT 的合并比例为 7.20%(95%置信区间:5.40-9.10%)。非均质型病变、较高级别的异型增生、病变位置(舌和多灶性)和女性性别对 OL 的 MT 有显著影响。

结论

OL 倾向于发展为 OSCC(7.2%),具有显著 MT 危险因素的患者应进行定期随访和观察。然而,我们需要进行大规模的前瞻性研究来验证这些结果,同时需要统一的临床病理诊断标准、标准化的危险因素记录/评估方法以及长期随访指南。

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