精准诊断和分期 TDP-43 蛋白病：利用人工智能的力量。
Precision diagnosis and staging of TDP-43 proteinopathies: harnessing the power of artificial intelligence.
机构信息
Department of Defense/Uniformed Services University Brain Tissue Repository, Uniformed Services University, Bethesda, MD 20817, USA.
Murtha Cancer Center Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD 20817, USA.
出版信息
Brain. 2023 Jul 3;146(7):2666-2668. doi: 10.1093/brain/awad175.
Abstract
This scientific commentary refers to ‘Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies’ by Young . (https://doi.org/10.1093/brain/awad145).
摘要
这篇科学评论提到了 Young 的“基于数据的 TDP-43 蛋白病神经病理学分期和亚型”一文。（https://doi.org/10.1093/brain/awad145）
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本文引用的文献
1
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2
Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer's disease.
Trends Neurosci. 2023 Jun;46(6):426-444. doi: 10.1016/j.tins.2023.03.005. Epub 2023 Apr 3.
3
Hallmarks of neurodegenerative diseases.
Cell. 2023 Feb 16;186(4):693-714. doi: 10.1016/j.cell.2022.12.032.
4
LATE-NC staging in routine neuropathologic diagnosis: an update.
Acta Neuropathol. 2023 Feb;145(2):159-173. doi: 10.1007/s00401-022-02524-2. Epub 2022 Dec 13.
5
Pan-cancer integrative histology-genomic analysis via multimodal deep learning.
Cancer Cell. 2022 Aug 8;40(8):865-878.e6. doi: 10.1016/j.ccell.2022.07.004.
6
TDP-43 pathology in anterior temporal pole cortex in aging and Alzheimer's disease.
Acta Neuropathol Commun. 2018 May 1;6(1):33. doi: 10.1186/s40478-018-0531-3.
7
Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration.
Acta Neuropathol. 2017 Jul;134(1):65-78. doi: 10.1007/s00401-017-1679-9. Epub 2017 Jan 27.
8
Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sclerosis: Evidence for clinico-pathologic subtypes.
Acta Neuropathol Commun. 2016 Jun 23;4(1):61. doi: 10.1186/s40478-016-0335-2.
9
Updated TDP-43 in Alzheimer's disease staging scheme.
Acta Neuropathol. 2016 Apr;131(4):571-85. doi: 10.1007/s00401-016-1537-1. Epub 2016 Jan 25.
10
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Science. 2006 Oct 6;314(5796):130-3. doi: 10.1126/science.1134108.
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