Department of Gastrointestinal Surgical Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350000, Fujian Province, China.
Department of Abdominal Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350000, Fujian Province, China.
Ecotoxicol Environ Saf. 2023 Jul 1;259:115054. doi: 10.1016/j.ecoenv.2023.115054. Epub 2023 May 23.
In recent years, Bisphenol S (BPS) has increasingly been used as an alternative to Bisphenol A (BPA) in food, paper, and personal care products. It is imperative to clarify the relationship between BPS and tumors in order to treat and prevent diseases. This study discovered a new method for predicting tumor correlations between BPS interactive genes. According to analyses conducted by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes, interactive genes were primarily found in gastric cancer. Based on gene-targeted prediction and molecular docking, BPS appears to exert potential gastric cancer-causing effects through estrogen receptor 1 (ESR1). In addition, gastric cancer patients' prognosis could be accurately predicted by a bisphenol-based prognostic prediction model. Subsequently, the proliferation and migration abilities of gastric cancer cells were further demonstrated to be significantly enhanced by BPS. Similarly, molecular docking analysis revealed that melatonin is also highly correlated with gastric cancer and BPS. In cell proliferation and migration assays, melatonin and BPS exposure inhibited the invasion abilities of gastric cancer cells compared to BPS-exposure. Our research provided a new direction for the exploration the correlation between cancer and environmental toxicity.
近年来，双酚 S（BPS）越来越多地被用作食品、纸张和个人护理产品中双酚 A（BPA）的替代品。为了治疗和预防疾病，必须明确 BPS 与肿瘤之间的关系。本研究发现了一种新的方法，可以预测 BPS 相互作用基因与肿瘤之间的相关性。通过基因本体论和京都基因与基因组百科全书的分析，发现相互作用基因主要存在于胃癌中。基于基因靶向预测和分子对接，BPS 通过雌激素受体 1（ESR1）似乎发挥了潜在的胃癌致癌作用。此外，基于双酚的预后预测模型可以准确预测胃癌患者的预后。随后，进一步证实 BPS 可显著增强胃癌细胞的增殖和迁移能力。同样，分子对接分析表明，褪黑素也与胃癌和 BPS 高度相关。在细胞增殖和迁移实验中，与 BPS 暴露相比，褪黑素和 BPS 暴露抑制了胃癌细胞的侵袭能力。我们的研究为探索癌症与环境毒性之间的相关性提供了新的方向。
