Kennedy G L, Ferenz R L, Burgess B A
J Appl Toxicol. 1986 Jun;6(3):145-8. doi: 10.1002/jat.2550060302.
The approximate lethal dose (ALD) to rats following oral administration of nine chemicals was determined. The ALD (lowest dose at which death was produced) for each chemical was used to define the general order of toxicity as being either extremely, highly, moderately, slightly, or practically non-toxic. For each of the nine chemicals tested, the category indicated by the ALD was identical with the category determined in the more extensive LD50 studies. In this study, an average of 6.8 rats was needed to determine the ALD while an average of 56.3 rats was needed to determine the LD50.
测定了九种化学物质经口给予大鼠后的近似致死剂量（ALD）。每种化学物质的ALD（产生死亡的最低剂量）用于定义毒性的一般等级，即极毒、高毒、中度毒性、轻度毒性或实际无毒。对于所测试的九种化学物质中的每一种，ALD所表明的类别与在更广泛的半数致死剂量（LD50）研究中确定的类别相同。在本研究中，确定ALD平均需要6.8只大鼠，而确定LD50平均需要56.3只大鼠。
