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马郁兰水提取物的化学成分、抗氧化能力、急性毒性及抗伤害感受特性分析

Analysis of Chemical Composition, Antioxidant Capacity, Acute Toxicity, and Antinociceptive Properties of Aqueous Extract of Origanum Majorana L.

作者信息

El Amiri My Ahmed, Kabdy Hamid, Aitbaba Abdelfatah, Laadraoui Jawad, Aboufatima Rachida, El Yazouli Loubna, Abdelmounaim Baslam, Moubtakir Soad, Garzoli Stefania, Abderrahman Chait

机构信息

Laboratory of biochemistry, Faculty of medicine and pharmacy, University Cadi Ayyad, Marrakech, Morocco.

Laboratory of Pharmacology, Neurobiology and Behavior, Faculty of Sciences Semlalia, University Cadi Ayyad, Marrakech, Morocco.

出版信息

Chem Biodivers. 2025 Mar;22(3):e202401580. doi: 10.1002/cbdv.202401580. Epub 2024 Nov 18.

DOI:10.1002/cbdv.202401580
PMID:39446705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11908776/
Abstract

Pharmacological evaluation showed that AEOM significantly reduced pain in an animal model, suggesting potential analgesic properties. Acute toxicity studies indicated no adverse effects on kidney and liver function or blood parameters at doses up to 800 mg/kg. The analgesic effect is likely mediated by flavonoids in the extract, which may inhibit pain pathways. These findings suggest that O. majorana has promising therapeutic applications, particularly as a natural analgesic agent.

摘要

药理学评估表明，AEOM在动物模型中能显著减轻疼痛，提示其具有潜在的镇痛特性。急性毒性研究表明，在高达800毫克/千克的剂量下，对肾功能、肝功能或血液参数均无不良影响。提取物中的黄酮类化合物可能介导了镇痛作用，其可能抑制疼痛传导通路。这些发现表明，大花牛至具有广阔的治疗应用前景，尤其是作为一种天然镇痛剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0620/11908776/b06acdb903b8/CBDV-22-e202401580-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0620/11908776/2826c1344fce/CBDV-22-e202401580-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0620/11908776/6dd89663d761/CBDV-22-e202401580-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0620/11908776/6c9c1bfbb5c7/CBDV-22-e202401580-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0620/11908776/b06acdb903b8/CBDV-22-e202401580-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0620/11908776/2826c1344fce/CBDV-22-e202401580-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0620/11908776/6dd89663d761/CBDV-22-e202401580-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0620/11908776/6c9c1bfbb5c7/CBDV-22-e202401580-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0620/11908776/b06acdb903b8/CBDV-22-e202401580-g005.jpg

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本文引用的文献

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2
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Front Plant Sci. 2021 Mar 25;12:646221. doi: 10.3389/fpls.2021.646221. eCollection 2021.
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Subacute Assessment of the Toxicity and Antidepressant-Like Effects of L. Polyphenols in Swiss Albino Mice.
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Molecules. 2020 Nov 30;25(23):5653. doi: 10.3390/molecules25235653.
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Chemical Composition and Antimicrobial Activity of Artemisia herba-alba and Origanum majorana Essential Oils from Morocco.摩洛哥小白蒿和马郁兰精油的化学成分和抗菌活性。
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