McDonald R, Hegenauer J, Saltman P
J Gerontol. 1986 Jul;41(4):445-52. doi: 10.1093/geronj/41.4.445.
The effect of 12 weeks of treadmill exercise on the mineralization of trabecular and cortical bone was studied in rats 7, 14, and 19 months of age. Bone mineralization was evaluated by measuring concentrations of Ca, Mg, and hydroxyproline as well as uptake of 45Ca concentration in the femur, humerus, rib and calvaria. The 7- and 14-month-old rats increased mineralization in those cortical bones directly involved in exercise. The 19-month animal responded to exercise by increasing mineralization in all bones examined, including the nonweight bearing trabecular calvaria and cortical rib. From these data, it is apparent that the older animals undergo a total skeletal mineralization in response to exercise compared with local adaptation in the younger animal. Further, we provide evidence to support the use of the rat as a model in which to study mammalian bone physiology during the aging process.
研究了为期12周的跑步机运动对7、14和19月龄大鼠小梁骨和皮质骨矿化的影响。通过测量钙、镁和羟脯氨酸的浓度以及股骨、肱骨、肋骨和颅骨中45Ca的摄取量来评估骨矿化。7月龄和14月龄的大鼠在直接参与运动的那些皮质骨中增加了矿化。19月龄的动物通过增加所有检查骨骼中的矿化来对运动做出反应，包括非负重的小梁颅骨和皮质肋骨。从这些数据可以明显看出，与年轻动物的局部适应性相比，老年动物在运动时会发生全身骨骼矿化。此外，我们提供了证据支持将大鼠作为研究衰老过程中哺乳动物骨骼生理学的模型。
