通过测量抗凝血酶III水平评估产后血栓栓塞风险。一种不切实际的期望

[Assessment of the risk of postpartum thromboembolism by measuring antithrombin III levels. A false hope].

作者信息

Massignon D, Clerc-Renaud P, Desenfant H, Coeur P, Dumont M

出版信息

J Gynecol Obstet Biol Reprod (Paris). 1986;15(2):171-2.

Abstract

In order to predict better thrombo-embolic complications that sometimes occur after delivery, we studied the variations of antithrombin III levels (A.T. III) in 703 women, at the 8th month pregnancy (275 levels), on the first day (609 levels) and the 5th day (516 levels) after delivery. The average antithrombin III levels were respectively 90.8%, 83.4% and 98.7%. We found 120 levels (8.5%) lower than 80% (normal range for A.T. III = 80-120%), 107 of which on the first day after delivery were followed by a rapid increase to the normal range; these women however were satisfactory in the post-partum period. Therefore predicting thrombo-embolic complications in the post-partum period through A.T. III levels determination would seem to be pointless.

摘要

为了更好地预测分娩后有时会出现的血栓栓塞并发症，我们研究了703名女性在妊娠第8个月（275次检测）、分娩第一天（609次检测）和分娩后第5天（516次检测）时抗凝血酶III水平（A.T. III）的变化。抗凝血酶III水平的平均值分别为90.8%、83.4%和98.7%。我们发现有120次检测结果（8.5%）低于80%（抗凝血酶III的正常范围为80 - 120%），其中107次是在分娩后的第一天出现低于正常范围的情况，随后迅速升至正常范围；不过这些女性在产后期间情况良好。因此，通过测定抗凝血酶III水平来预测产后血栓栓塞并发症似乎没有意义。