Kherbek Haidara, Hinawi Marah, Layka Khedr, Hleibieh Yana, Jaber Khawla, Jaber Roukaya, Alshehabi Zuheir
Faculty of Medicine.
Department of Pathology, Cancer Research Center, Tishreen University, Latakia, Syria.
Ann Med Surg (Lond). 2023 Apr 11;85(5):2198-2202. doi: 10.1097/MS9.0000000000000663. eCollection 2023 May.
Burkitt's lymphoma (BL), an aggressive kind of non-Hodgkin's B-cell lymphoma. On the other hand, appendiceal carcinoid tumors are uncommon neuroendocrine neoplasms.
The authors report a case of a 15-year-old Syrian adolescent who was admitted to our hospital due to a persistent, severe generalized abdomen pain accompanied by nausea, vomiting, loss of appetite, and inability to pass stool or gas. An abdominal radiograph revealed dilated intestinal loops with air-fluid levels. The patient underwent emergency surgery through which a retroperitoneal mass was removed as well as part of the ileum and the appendix. The final diagnosis was consistent with intestinal BL associated with an appendiceal carcinoid tumor.
The correlation between gastrointestinal carcinoids and other types of tumors was frequently reported. However, there have been few reports of carcinoid tumors being associated with lymphoreticular system cancers. BLs were classified into three variants: endemic, sporadic, and acquired immunodeficiency-associated BL while appendiceal neuroendocrine tumors were classified as the following: well-differentiated neuroendocrine tumors with benign or uncertain malignant potential; well-differentiated neuroendocrine carcinoma with low malignant potential; and mixed exocrine-neuroendocrine carcinoma.
Our article demonstrates an unusual association between BL and an appendiceal carcinoid tumor that highlights the significant role of histological and immunohistochemical staining in confirming the diagnosis, as well as the role of surgery in treating the complications of intestinal BLs.
伯基特淋巴瘤（BL）是一种侵袭性非霍奇金B细胞淋巴瘤。另一方面，阑尾类癌肿瘤是罕见的神经内分泌肿瘤。
作者报告了一例15岁叙利亚青少年病例，该患者因持续性严重的全腹疼痛伴恶心、呕吐、食欲不振以及无法排便或排气而入院。腹部X光片显示肠袢扩张并伴有气液平面。患者接受了急诊手术，术中切除了一个腹膜后肿块以及部分回肠和阑尾。最终诊断为与阑尾类癌肿瘤相关的肠道BL。
胃肠道类癌与其他类型肿瘤之间的相关性经常被报道。然而，类癌肿瘤与淋巴网状系统癌症相关的报道很少。BL分为三种类型：地方性、散发性和获得性免疫缺陷相关的BL，而阑尾神经内分泌肿瘤则分类如下：具有良性或不确定恶性潜能的高分化神经内分泌肿瘤；具有低恶性潜能的高分化神经内分泌癌；以及混合性外分泌-神经内分泌癌。
我们的文章展示了BL与阑尾类癌肿瘤之间一种不寻常的关联，突出了组织学和免疫组化染色在确诊中的重要作用，以及手术在治疗肠道BL并发症中的作用。
