Li Junfei, Xie Yajie, Zou Xiaoran, Li Zhengze, Liu Wenbo, Liu Guodong, Ma Mengjiao, Zheng Yudong
School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China.
Center for Medical Device Evaluation, National Medical Products Administration, Intellectual Property Publishing House Mansion, Qixiang Road, Haidian District, Beijing, China.
Mater Today Bio. 2023 May 13;20:100665. doi: 10.1016/j.mtbio.2023.100665. eCollection 2023 Jun.
Electret materials have attracted extensive attention because of their permanent polarization and electrostatic effect. However, it is one of problem that needs to be solved in biological application to manipulate the change of surface charge of electret by external stimulation. In this work, a drug-loaded electret with flexibility and no cytotoxicity was prepared under relatively mild conditions. The electret can release the charge through stress change and ultrasonic stimulation, and the drug release can be accurately controlled with the help of ultrasonic and electric double stimulation response. Here, the dipoles like particles of carnauba wax nanoparticles (nCW) are fixed in the matrix based on the interpenetrating polymer network structure, and "frozen" oriented dipolar particles that are treated by thermal polarization and cooled at high field strength. Subsequently, the charge density of the prepared composite electret can reach 101.1 nC/m at the initial stage of polarization and 21.1 nC/m after 3 weeks. In addition, the stimulated change of electret surface charge flow under cyclic tensile stress and cyclic compressive stress can generate a current of 0.187 nA and 0.105 nA at most. The ultrasonic stimulation results show that when the ultrasonic emission power was 90% (P = 1200 W), the current of 0.472 nA can be generated. Finally, the drug release characteristics and biocompatibility of the nCW composite electret containing curcumin were tested. The results showed that it not only had the ability to accurately control the release by ultrasound, but also triggered the electrical effect of the material. The prepared drug loaded composite bioelectret provides a new way for the construction, design and testing of the bioelectret. Its ultrasonic and electrical double stimulation response can be accurately controlled and released as required, and it has broad application prospects.
驻极体材料因其永久极化和静电效应而备受广泛关注。然而，通过外部刺激来操纵驻极体表面电荷的变化是生物应用中需要解决的问题之一。在这项工作中，在相对温和的条件下制备了一种具有柔韧性且无细胞毒性的载药驻极体。该驻极体可通过应力变化和超声刺激释放电荷，并且借助超声和电双刺激响应能够精确控制药物释放。在此，巴西棕榈蜡纳米颗粒（nCW）的偶极子状颗粒基于互穿聚合物网络结构固定在基质中，并通过热极化处理且在高场强下冷却得到“冻结”的取向偶极颗粒。随后，制备的复合驻极体在极化初始阶段的电荷密度可达101.1 nC/m，3周后为21.1 nC/m。此外，在循环拉伸应力和循环压缩应力下驻极体表面电荷流的刺激变化最多可产生0.187 nA和0.105 nA的电流。超声刺激结果表明，当超声发射功率为90%（P = 1200 W）时，可产生0.472 nA的电流。最后，测试了含姜黄素的nCW复合驻极体的药物释放特性和生物相容性。结果表明，它不仅具有通过超声精确控制释放的能力，还能引发材料的电效应。制备的载药复合生物驻极体为生物驻极体的构建、设计和测试提供了一种新途径。其超声和电双刺激响应可根据需要精确控制和释放，具有广阔的应用前景。
