Pediatric Research Institute, Children's Hospital Affiliated to Shandong University, Ji'nan 250022, China; Shandong University of Traditional Chinese Medicine, Ji'nan 250355, China; Tumor Minimally Invasive Comprehensive Treatment Department, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan 250021, China.
Pediatric Research Institute, Children's Hospital Affiliated to Shandong University, Ji'nan 250022, China.
Stem Cell Res. 2023 Jun;69:103115. doi: 10.1016/j.scr.2023.103115. Epub 2023 May 6.
The induced pluripotent stem cells (iPSCs) line was generated using peripheral blood mononuclear cells (PBMCs) from a healthy 1-month-old boy. Expression of pluripotency markers, deletion of free episomal vectors, preservation of normal karyotype, and potential for in vitro trilineage differentiation were demonstrated in the iPSCs line SDQLCHi048-A. This cell line may serve as a basis for disease modeling and help to further explore the molecular pathogenesis.
诱导多能干细胞（iPSC）系是使用来自健康 1 个月大男婴的外周血单个核细胞（PBMC）生成的。在 iPSC 系 SDQLCHi048-A 中证明了多能性标记物的表达、游离附加体载体的缺失、正常核型的保留以及体外三系分化的潜能。该细胞系可作为疾病建模的基础，并有助于进一步探索分子发病机制。
