Schellenberg Jana, Ahathaller Magdalena, Matits Lynn, Kirsten Johannes, Kersten Johannes, Steinacker Juergen Michael
Division of Sports and Rehabilitation Medicine, University Ulm Hospital, 89075 Ulm, Germany.
Clinical & Biological Psychology, Institute of Psychology and Education, Ulm University, 89075 Ulm, Germany.
J Cardiovasc Dev Dis. 2023 Apr 23;10(5):189. doi: 10.3390/jcdd10050189.
Whether symptoms during COVID-19 contribute to impaired left ventricular (LV) function remains unclear. We determine LV global longitudinal strain (GLS) between athletes with a positive COVID-19 test (PCAt) and healthy control athletes (CON) and relate it to symptoms during COVID-19. GLS is determined in four-, two-, and three-chamber views and assessed offline by a blinded investigator in 88 PCAt (35% women) (training at least three times per week/>20 MET) and 52 CONs from the national or state squad (38% women) at a median of two months after COVID-19. The results show that the GLS is significantly lower (GLS -18.53 ± 1.94% vs. -19.94 ± 1.42%, < 0.001) and diastolic function significantly reduces (E/A 1.54 ± 0.52 vs. 1.66 ± 0.43, = 0.020; E/E'l 5.74 ± 1.74 vs. 5.22 ± 1.36, = 0.024) in PCAt. There is no association between GLS and symptoms like resting or exertional dyspnea, palpitations, chest pain or increased resting heart rate. However, there is a trend toward a lower GLS in PCAt with subjectively perceived performance limitation ( =0.054). A significantly lower GLS and diastolic function in PCAt compared with healthy peers may indicate mild myocardial dysfunction after COVID-19. However, the changes are within the normal range, so that clinical relevance is questionable. Further studies on the effect of lower GLS on performance parameters are necessary.
新型冠状病毒肺炎（COVID-19）期间的症状是否会导致左心室（LV）功能受损仍不清楚。我们测定了COVID-19检测呈阳性的运动员（PCAt）和健康对照运动员（CON）之间的左心室整体纵向应变（GLS），并将其与COVID-19期间的症状相关联。在四腔、两腔和三腔视图中测定GLS，并由一名不知情的研究人员在88名PCAt（35%为女性）（每周至少训练三次/>20代谢当量）和52名来自国家或州代表队的CON（38%为女性）中进行离线评估，评估时间为COVID-19后两个月的中位数。结果显示，PCAt的GLS显著降低（GLS -18.53±1.94% vs. -19.94±1.42%，<0.001），舒张功能显著降低（E/A 1.54±0.52 vs. 1.66±0.43，=0.020；E/E'l 5.74±1.74 vs. 5.22±1.36，=0.024）。GLS与静息或运动性呼吸困难、心悸、胸痛或静息心率增加等症状之间无关联。然而，在主观感觉运动能力受限的PCAt中，GLS有降低的趋势（=0.054）。与健康同龄人相比，PCAt的GLS和舒张功能显著降低可能表明COVID-19后存在轻度心肌功能障碍。然而，这些变化在正常范围内，因此临床相关性值得怀疑。有必要进一步研究较低的GLS对运动参数的影响。
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