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聚乙烯醇-壳聚糖支架在组织工程和再生医学中的应用：综述。

Polyvinyl Alcohol-Chitosan Scaffold for Tissue Engineering and Regenerative Medicine Application: A Review.

机构信息

Department of Orthopedic Surgery, Faculty of Medicine, University Malaya, Kuala Lumpur 50603, Malaysia.

Department of Physiology, Faculty of Medicine, University Malaya, Kuala Lumpur 50603, Malaysia.

出版信息

Mar Drugs. 2023 May 17;21(5):304. doi: 10.3390/md21050304.

DOI:10.3390/md21050304
PMID:37233498
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10222047/
Abstract

Tissue engineering and regenerative medicine (TERM) holds great promise for addressing the growing need for innovative therapies to treat disease conditions. To achieve this, TERM relies on various strategies and techniques. The most prominent strategy is the development of a scaffold. Polyvinyl alcohol-chitosan (PVA-CS) scaffold emerged as a promising material in this field due to its biocompatibility, versatility, and ability to support cell growth and tissue regeneration. Preclinical studies showed that the PVA-CS scaffold can be fabricated and tailored to fit the specific needs of different tissues and organs. Additionally, PVA-CS can be combined with other materials and technologies to enhance its regenerative capabilities. Furthermore, PVA-CS represents a promising therapeutic solution for developing new and innovative TERM therapies. Therefore, in this review, we summarized the potential role and functions of PVA-CS in TERM applications.

摘要

组织工程与再生医学（TERM）在满足创新性疾病治疗方法的日益增长的需求方面具有巨大的潜力。为了实现这一目标，TERM 依赖于各种策略和技术。最突出的策略是开发支架。聚乙烯醇-壳聚糖（PVA-CS）支架因其生物相容性、多功能性以及支持细胞生长和组织再生的能力，成为该领域很有前途的材料。临床前研究表明，PVA-CS 支架可以被制造并定制，以满足不同组织和器官的特定需求。此外，PVA-CS 可以与其他材料和技术结合使用，以增强其再生能力。此外，PVA-CS 为开发新的和创新的 TERM 治疗方法提供了有前途的治疗解决方案。因此，在这篇综述中，我们总结了 PVA-CS 在 TERM 应用中的潜在作用和功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a11f/10222047/c4ac7fc872d0/marinedrugs-21-00304-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a11f/10222047/cab9188677d5/marinedrugs-21-00304-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a11f/10222047/924bf9491b63/marinedrugs-21-00304-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a11f/10222047/c4ac7fc872d0/marinedrugs-21-00304-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a11f/10222047/cab9188677d5/marinedrugs-21-00304-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a11f/10222047/924bf9491b63/marinedrugs-21-00304-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a11f/10222047/c4ac7fc872d0/marinedrugs-21-00304-g003.jpg

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Biomater Biosyst. 2025-8-8

[2]
Polyvinyl Alcohol-Based Membranes: A Review of Research Progress on Design and Predictive Modeling of Properties for Targeted Application.

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[3]
4D printing polymeric biomaterials for adaptive tissue regeneration.

Bioact Mater. 2025-2-22

[4]
Enhancing mechanical properties of chitosan/PVA electrospun nanofibers: a comprehensive review.

Beilstein J Nanotechnol. 2025-2-26

[5]
Synthesis of PVA-Based Hydrogels for Biomedical Applications: Recent Trends and Advances.

Gels. 2025-1-23

[6]
Histology Assessment of Chitosan-Polyvinyl Alcohol Scaffolds Incorporated with CaO Nanoparticles.

Molecules. 2025-1-12

[7]
Biological activity of lyophilized chitosan scaffolds with inclusion of chitosan and zinc oxide nanoparticles.

RSC Adv. 2024-4-25

[8]
Microscopic and Macroscopic Characterization of Hydrogels Based on Poly(vinyl-alcohol)-Glutaraldehyde Mixtures for Fricke Gel Dosimetry.

Gels. 2024-2-28

[9]
Biomaterials for Drug Delivery and Human Applications.

Materials (Basel). 2024-1-18

本文引用的文献

[1]
Development of a flexible film made of polyvinyl alcohol with chitosan based thermosensitive hydrogel.

J Dent Sci. 2023-4

[2]
Chitosan Based Materials in Cosmetic Applications: A Review.

Molecules. 2023-2-15

[3]
PVA/Chitosan Thin Films Containing Silver Nanoparticles and Ibuprofen for the Treatment of Periodontal Disease.

Polymers (Basel). 2022-12-20

[4]
TGF-β1 and -β3 for Mesenchymal Stem Cells Chondrogenic Differentiation on Poly (Vinyl Alcohol)-Chitosan-Poly (Ethylene Glycol) Scaffold.

Tissue Eng Part C Methods. 2022-10

[5]
The Use of Polymer Blends in the Treatment of Ocular Diseases.

Pharmaceutics. 2022-7-7

[6]
Antimicrobial properties of chitosan from different developmental stages of the bioconverter insect Hermetia illucens.

Sci Rep. 2022-5-16

[7]
Evaluation of Biomechanical and Chemical Properties of Gamma-Irradiated Polycaprolactone Microfilaments for Musculoskeletal Tissue Engineering Applications.

Int J Biomater. 2022-4-29

[8]
The anti-inflammatory and osteogenic activity of chitosan/polyvinyl alcohol/graphene oxide/astaxanthin nanofibers membranes in vitro study.

J Biomater Appl. 2022-5

[9]
Considerations for Polymers Used in Ocular Drug Delivery.

Front Med (Lausanne). 2022-1-28

[10]
Injectable Adhesive Hydrogel through a Microcapsule Cross-Link for Periodontitis Treatment.

ACS Appl Bio Mater. 2019-12-16

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