Department of Urology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
PLoS One. 2024 Nov 14;19(11):e0313074. doi: 10.1371/journal.pone.0313074. eCollection 2024.
Erectile dysfunction (ED) is a prevalent condition in urology, and studies on the effectiveness of platelet-rich plasma (PRP) for this condition have been conducted; however, the evidence remains inconclusive. This meta-analysis aimed to evaluate the effectiveness of PRP in treating ED.
On May 17, 2024, a literature search was performed and evaluated using the Cochrane method. The primary outcome measured was the International Index of Erectile Function (IIEF) score, while the secondary outcomes included Minimal Clinically Important Difference (MCID) and peak systolic velocity (PSV).
A total of 12 controlled trials involving 991 patients and 11 single-arm trials with 377 patients were analyzed. The findings revealed that compared to the control group, the PRP group demonstrated better outcomes in terms of the IIEF score and MCID (SMD = 0.59 (95% CI: [0.34, 0.84]; RR = 1.94 (95% CI: [1.33, 2.83]), In the single-arm trials, a significant improvement in IIEF scores was observed following PRP treatment (SMD = -0.99 95% CI: [-1.53, 0.46]).
PRP appears effective in treating erectile dysfunction, but further high-quality, large-sample trials with longer follow-up are needed to fully understand its effects.
勃起功能障碍（ED）是泌尿科常见病症，已有研究探讨富血小板血浆（PRP）治疗该病症的效果，但证据仍不明确。本荟萃分析旨在评估 PRP 治疗 ED 的效果。
于 2024 年 5 月 17 日，我们采用 Cochrane 方法检索并评估文献。主要结局指标为国际勃起功能指数（IIEF）评分，次要结局指标包括最小临床重要差异（MCID）和收缩期峰值流速（PSV）。
共纳入 12 项对照试验（991 例患者）和 11 项单臂试验（377 例患者）。结果显示，与对照组相比，PRP 组 IIEF 评分和 MCID 改善更优（SMD = 0.59 [95%CI：0.34, 0.84]；RR = 1.94 [95%CI：1.33, 2.83]）。在单臂试验中，PRP 治疗后 IIEF 评分显著改善（SMD = -0.99 [95%CI：-1.53, 0.46]）。
PRP 似乎对 ED 有效，但还需要更多高质量、大样本、随访时间更长的试验，以全面了解其疗效。
