Si Mao-Yan, Rao Ding-Yu, Xia Yao, Sang Cheng-Peng, Mao Kai-Yun, Liu Xiang-Jin, Zhang Zu-Xiong, Tang Zhi-Xian
First Clinical Medical College, Gannan Medical University, Ganzhou, China.
Department of Cardiothoracic Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Front Oncol. 2023 May 9;13:1126890. doi: 10.3389/fonc.2023.1126890. eCollection 2023.
Esophageal cancer is a common malignant tumor with a high degree of malignancy. Understanding its pathogenesis and identifying early diagnostic biomarkers can significantly improve the prognosis of esophageal cancer patients. Exosomes are small double-membrane vesicles found in various body fluids containing various components (DNA, RNA, and proteins) that mediate intercellular signal communication. Non-coding RNAs are a class of gene transcription products that encode polypeptide functions and are widely detected in exosomes. There is growing evidence that exosomal non-coding RNAs are involved in cancer growth, metastasis and angiogenesis, and can also be used as diagnostic and prognostic markers. This article reviews the recent progress in exosomal non-coding RNAs in esophageal cancer, including research progress, diagnostic value, proliferation, migration, invasion, and drug resistance, provide new ideas for the precise treatment of esophageal cancer.
食管癌是一种常见的恶性肿瘤，恶性程度高。了解其发病机制并识别早期诊断生物标志物可显著改善食管癌患者的预后。外泌体是存在于各种体液中的小双膜囊泡，含有多种成分（DNA、RNA和蛋白质），介导细胞间信号通讯。非编码RNA是一类不编码多肽功能的基因转录产物，在外泌体中广泛检测到。越来越多的证据表明，外泌体非编码RNA参与癌症的生长、转移和血管生成，也可作为诊断和预后标志物。本文综述了外泌体非编码RNA在食管癌中的最新研究进展，包括研究进展、诊断价值、增殖、迁移、侵袭和耐药性等，为食管癌的精准治疗提供新思路。
