Department of Clinical Laboratory, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui, P.R. China.
Department of Clinical Laboratory, Division of Life Sciences and Medicine, The First Affliated Hospital of USTC, University of Science and Technology of China, Hefei, Anhui, P.R. China.
Cancer Med. 2020 Oct;9(19):6909-6922. doi: 10.1002/cam4.3379. Epub 2020 Aug 10.
More and more studies report that exosomes released by various cells can serve as a medium for information exchange between different cells. Through a deep understanding of the physical and chemical properties of exosomes, the researchers revealed a more precise molecular mechanism of its participation in the process of intercellular communication. In particular, microRNA (miRNA) is found inside exosomes, as well as long noncoding RNA (lncRNA). Extensive evidence indicates that exosomal miRNAs participates in the occurrence and development of lung cancer and plays a variety of roles. Therefore, the release of RNA-containing exosomes in many different kinds of body fluids has caused widespread interest among researchers. In this review, we report evidence from human studies involving miRNAs and other ncRNAs in exosomes associated with lung cancer as diagnostic and prognostic markers. Currently, there is a small amount of evidence that exosomal miRNAs can be used as early diagnosis and prognostic markers for lung cancer, and their exact role in lung cancer patients still needs further study.
越来越多的研究报告指出，各种细胞释放的外泌体可以作为不同细胞之间信息交流的媒介。通过深入了解外泌体的物理和化学性质，研究人员揭示了其参与细胞间通讯过程的更精确的分子机制。特别是，微 RNA（miRNA）和长链非编码 RNA（lncRNA）都存在于外泌体中。大量证据表明，外泌体 miRNA 参与肺癌的发生和发展，并发挥多种作用。因此，许多不同体液中外泌体 RNA 的释放引起了研究人员的广泛关注。在这篇综述中，我们报告了涉及与肺癌相关的外泌体中 miRNA 和其他 ncRNA 的人类研究证据，作为诊断和预后标志物。目前，有少量证据表明外泌体 miRNA 可以作为肺癌的早期诊断和预后标志物，但其在肺癌患者中的确切作用仍需要进一步研究。
