Key Laboratory of High Efficiency and Clean Manufacturing, School of Mechanical Engineering, National Demonstration Center for Experimental Mechanical Engineering Education, Shandong University, Jinan 250061, People's Republic of China.
Collage of Artificial Intelligence and Big Data for Medical Sciences, Shandong First Medical University, Jinan 250117, People's Republic of China.
Biomed Mater. 2023 Jun 14;18(4). doi: 10.1088/1748-605X/acd976.
Titanium and its alloys have been widely used in bone tissue defect treatment owing to their excellent comprehensive properties. However, because of the biological inertness of the surface, it is difficult to achieve satisfactory osseointegration with the surrounding bone tissue when implanted into the body. Meanwhile, an inflammatory response is inevitable, which leads to implantation failure. Therefore, solving these two problems has become a new research hotspot. In current studies, various surface modification methods were proposed to meet the clinical needs. Yet, these methods have not been classified as a system to guide the follow-up research. These methods are demanded to be summarized, analyzed, and compared. In this manuscript, the effect of physical signal regulation (multi-scale composite structure) and chemical signal regulation (bioactive substance) generated by surface modification in promoting osteogenesis and reducing inflammatory responses was generalized and discussed. Finally, from the perspective of material preparation and biocompatibility experiments, the development trend of surface modification in promoting titanium implant surface osteogenesis and anti-inflammatory research was proposed.
钛及钛合金因其具有优异的综合性能而被广泛应用于骨组织缺损的治疗。然而，由于其表面的生物惰性，植入体内后与周围骨组织很难达到满意的骨整合。同时，不可避免地会引发炎症反应，从而导致植入物失败。因此，解决这两个问题已成为新的研究热点。在目前的研究中，提出了各种表面改性方法来满足临床需求。然而，这些方法尚未被归类为系统，以指导后续的研究。需要对这些方法进行总结、分析和比较。在本文中，概括和讨论了表面改性产生的物理信号调节（多尺度复合结构）和化学信号调节（生物活性物质）对促进成骨和减少炎症反应的影响。最后，从材料制备和生物相容性实验的角度，提出了促进钛植入体表面成骨和抗炎研究的表面改性的发展趋势。
