健康中国老年人无认知障碍者血浆淀粉样蛋白-β、总 tau 和磷酸化 tau181 的参考区间。
Reference intervals for plasma amyloid-β, total tau, and phosphorylated tau181 in healthy elderly Chinese individuals without cognitive impairment.
机构信息
Department of Neurology, Institute of Neuroimmunology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Division of Neuroimmunology, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, 100070, China.
出版信息
Alzheimers Res Ther. 2023 May 26;15(1):100. doi: 10.1186/s13195-023-01246-1.
BACKGROUND
Plasma amyloid-β (Aβ) peptides and tau proteins are promising biomarkers of Alzheimer's disease (AD), not only for predicting Aβ and tau pathology but also for differentiating AD from other neurodegenerative diseases. However, reference intervals for plasma biomarkers of AD in healthy elderly Chinese individuals have not yet been established.
METHODS
Biomarkers of AD were measured using single-molecule array (Simoa) assays in plasma samples from 193 healthy, cognitively unimpaired Chinese individuals aged 50-89 years. The 95% reference intervals for plasma Aβ42, Aβ40, t-tau, p-tau181, and derived ratios were calculated by using log-transformed parametric methods.
RESULTS
Plasma Aβ42, Aβ40, and p-tau181 levels were positively correlated with age, while the Aβ42/Aβ40 ratio was negatively correlated with age. The 95% reference intervals for plasma Aβ42 and Aβ40 were 2.72-11.09 pg/mL and 61.4-303.9 pg/mL, respectively, and the 95% reference intervals for plasma t-tau and p-tau181 were 0.20-3.12 pg/mL and 0.49-3.29 pg/mL, respectively. The 95% reference intervals for the Aβ42/Aβ40 ratio, p-tau181/t-tau ratio, and p-tau181/Aβ42 ratio were 0.022-0.064, 0.38-6.34, and 0.05-0.55, respectively.
CONCLUSION
Reference intervals for plasma biomarkers of AD may assist clinicians in making accurate clinical decisions.
背景
血浆淀粉样蛋白-β（Aβ）肽和 tau 蛋白是阿尔茨海默病（AD）有前途的生物标志物，不仅可用于预测 Aβ 和 tau 病理学，还可用于区分 AD 与其他神经退行性疾病。然而，尚未建立健康中国老年人血浆 AD 生物标志物的参考区间。
方法
使用单分子阵列（Simoa）测定 193 名 50-89 岁认知正常的中国健康个体的血浆样本中的 AD 生物标志物。通过对数转换参数方法计算血浆 Aβ42、Aβ40、t-tau、p-tau181 和衍生比值的 95%参考区间。
结果
血浆 Aβ42、Aβ40 和 p-tau181 水平与年龄呈正相关，而 Aβ42/Aβ40 比值与年龄呈负相关。血浆 Aβ42 和 Aβ40 的 95%参考区间分别为 2.72-11.09 pg/mL 和 61.4-303.9 pg/mL，血浆 t-tau 和 p-tau181 的 95%参考区间分别为 0.20-3.12 pg/mL 和 0.49-3.29 pg/mL。Aβ42/Aβ40 比值、p-tau181/t-tau 比值和 p-tau181/Aβ42 比值的 95%参考区间分别为 0.022-0.064、0.38-6.34 和 0.05-0.55。
结论
AD 血浆生物标志物的参考区间可能有助于临床医生做出准确的临床决策。
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