Tong Yao, Zhang Yingying, Bao Benkun, Hu Xuhui, Li Jiuqiang, Wu Han, Yang Kerong, Zhang Senhao, Yang Hongbo, Guo Kai
School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.
Bioengineering (Basel). 2023 May 21;10(5):620. doi: 10.3390/bioengineering10050620.
Nickel plating electrolytes prepared by using a simple salt solution can achieve nickel plating on laser-induced graphene (LIG) electrodes, which greatly enhances the electrical conductivity, electrochemical properties, wear resistance, and corrosion resistance of LIG. This makes the LIG-Ni electrodes well suited for electrophysiological, strain, and electrochemical sensing applications. The investigation of the mechanical properties of the LIG-Ni sensor and the monitoring of pulse, respiration, and swallowing confirmed that the sensor can sense insignificant deformations to relatively large conformal strains of skin. Modulation of the nickel-plating process of LIG-Ni, followed by chemical modification, may allow for the introduction of glucose redox catalyst NiFe(CN) with interestingly strong catalytic effects, which gives LIG-Ni impressive glucose-sensing properties. Additionally, the chemical modification of LIG-Ni for pH and Na monitoring also confirmed its strong electrochemical monitoring potential, which demonstrates application prospects in the development of multiple electrochemical sensors for sweat parameters. A more uniform LIG-Ni multi-physiological sensor preparation process provides a prerequisite for the construction of an integrated multi-physiological sensor system. The sensor was validated to have continuous monitoring performance, and its preparation process is expected to form a system for non-invasive physiological parameter signal monitoring, thus contributing to motion monitoring, disease prevention, and disease diagnosis.
使用简单盐溶液制备的镀镍电解质可以在激光诱导石墨烯（LIG）电极上实现镀镍，这大大提高了LIG的电导率、电化学性能、耐磨性和耐腐蚀性。这使得LIG-Ni电极非常适合用于电生理、应变和电化学传感应用。对LIG-Ni传感器力学性能的研究以及对脉搏、呼吸和吞咽的监测证实，该传感器能够感知皮肤从微小变形到相对较大的共形应变。对LIG-Ni的镀镍过程进行调制，随后进行化学修饰，可能会引入具有有趣强催化作用的葡萄糖氧化还原催化剂NiFe(CN)，这赋予了LIG-Ni令人印象深刻的葡萄糖传感特性。此外，对LIG-Ni进行pH和Na监测的化学修饰也证实了其强大的电化学监测潜力，这展示了其在开发多种用于汗液参数的电化学传感器方面的应用前景。更均匀的LIG-Ni多生理传感器制备过程为构建集成多生理传感器系统提供了前提条件。该传感器被验证具有连续监测性能，其制备过程有望形成一个用于无创生理参数信号监测的系统，从而有助于运动监测、疾病预防和疾病诊断。
