Peinado Beatriz Rodrigues Risuenho, Aragão Walessa Alana Bragança, Pereira Cristian Dos Santos, da Silva Diane Cleydes Baia, Ferreira Railson de Oliveira, Chaves-Neto Antônio Hernandes, Fernandes Luanna Melo Pereira, Lima Rafael Rodrigues
Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075110, Brazil.
Department of Basic Sciences, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16066840, Brazil.
Antioxidants (Basel). 2023 May 3;12(5):1038. doi: 10.3390/antiox12051038.
Heavy episodic ethanol (EtOH) consumption is a typical pattern, especially among younger people. The therapeutic effect of exercise on EtOH damage has not yet been fully elucidated. Therefore, this study aims to investigate whether moderate exercise can reduce the damage generated by ethanol consumption in salivary glands and saliva. Thus, 32 male Wistar rats were divided into four groups: control (sedentary animals treated with water); training (trained animals treated with EtOH); EtOH (sedentary animals treated with EtOH); and EtOH + training (trained animals treated with ethanol). EtOH was administered to the animals at a dose of 3 g/kg/day at a concentration of 20% for three consecutive days per week via intragastric gavage. The training was performed on a treadmill for five successive days. At the end of the 4-week experimental protocol, the animals were euthanized, and salivary glands and saliva were collected for oxidative biochemistry analysis. Our results showed that EtOH consumption generated changes in the oxidative biochemistry of the salivary glands and saliva. Thus, it was possible to conclude that moderate physical exercise can significantly recover antioxidant activity, reducing the damage generated by EtOH.
大量间歇性饮酒是一种典型模式，在年轻人中尤为常见。运动对乙醇损伤的治疗作用尚未完全阐明。因此，本研究旨在探讨适度运动是否能减少乙醇摄入对唾液腺和唾液造成的损伤。于是，将32只雄性Wistar大鼠分为四组：对照组（久坐不动且用水处理的动物）；训练组（接受训练且用乙醇处理的动物）；乙醇组（久坐不动且用乙醇处理的动物）；乙醇+训练组（接受训练且用乙醇处理的动物）。每周连续三天通过灌胃法以20%的浓度按3 g/kg/天的剂量给动物施用乙醇。连续五天在跑步机上进行训练。在4周实验方案结束时，对动物实施安乐死，并收集唾液腺和唾液进行氧化生物化学分析。我们的结果表明，乙醇摄入导致唾液腺和唾液的氧化生物化学发生变化。因此，可以得出结论，适度体育锻炼可显著恢复抗氧化活性，减少乙醇造成的损伤。
