Vejrazkova Daniela, Vankova Marketa, Lukasova Petra, Hill Martin, Vcelak Josef, Tura Andrea, Chocholova Denisa, Bendlova Bela
Institute of Endocrinology, 110 00 Prague, Czech Republic.
Institute of Neuroscience, National Research Council (CNR), 351 22 Padova, Italy.
Biomedicines. 2023 Apr 25;11(5):1278. doi: 10.3390/biomedicines11051278.
The shape of the glycemic curve during the oral glucose tolerance test (OGTT), interpreted in the correct context, can predict impaired glucose homeostasis. Our aim was to reveal information inherent in the 3 h glycemic trajectory that is of physiological relevance concerning the disruption of glycoregulation and complications beyond, such as components of metabolic syndrome (MS).
In 1262 subjects (1035 women, 227 men) with a wide range of glucose tolerance, glycemic curves were categorized into four groups: monophasic, biphasic, triphasic, and multiphasic. The groups were then monitored in terms of anthropometry, biochemistry, and timing of the glycemic peak.
Most curves were monophasic (50%), then triphasic (28%), biphasic (17.5%), and multiphasic (4.5%). Men had more biphasic curves than women (33 vs. 14%, respectively), while women had more triphasic curves than men (30 vs. 19%, respectively) ( < 0.01). Monophasic curves were more frequent in people with impaired glucose regulation and MS compared to bi-, tri-, and multiphasic ones. Peak delay was the most common in monophasic curves, in which it was also most strongly associated with the deterioration of glucose tolerance and other components of MS.
The shape of the glycemic curve is gender dependent. A monophasic curve is associated with an unfavorable metabolic profile, especially when combined with a delayed peak.
口服葡萄糖耐量试验（OGTT）期间血糖曲线的形状，在正确的背景下解读，可预测葡萄糖稳态受损。我们的目的是揭示3小时血糖轨迹中固有的信息，这些信息与糖调节破坏及其他并发症（如代谢综合征（MS）的组成部分）具有生理相关性。
在1262名糖耐量范围广泛的受试者（1035名女性，227名男性）中，血糖曲线被分为四组：单相、双相、三相和多相。然后对这些组进行人体测量、生化指标和血糖峰值时间的监测。
大多数曲线为单相（50%），其次是三相（28%）、双相（17.5%）和多相（4.5%）。男性的双相曲线比女性多（分别为33%和14%），而女性的三相曲线比男性多（分别为30%和19%）（P<0.01）。与双相、三相和多相曲线相比，葡萄糖调节受损和患有MS的人群中单相曲线更为常见。峰值延迟在单相曲线中最为常见，其中它也与葡萄糖耐量恶化和MS的其他组成部分最密切相关。
血糖曲线的形状存在性别差异。单相曲线与不良的代谢特征相关，尤其是与峰值延迟相结合时。
