Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
J Diabetes Investig. 2020 Jul;11(4):874-877. doi: 10.1111/jdi.13227. Epub 2020 Mar 1.
Individuals with a monophasic glucose response curve (GRC) during a 75-g oral glucose tolerance test have a higher risk for type 2 diabetes than those with a biphasic GRC. However, no studies have addressed the association between GRC type and insulin clearance. Thus, we studied 49 healthy non-obese Japanese men. We divided study participants into the monophasic or biphasic group based on the shape of their GRC. We evaluated tissue-specific insulin sensitivity and insulin clearance using a two-step hyperinsulinemic-euglycemic clamp. The monophasic group had more visceral fat, lower insulin clearance and lower muscle insulin sensitivity than the biphasic group, whereas liver and adipose tissue insulin sensitivity, and insulin secretion were comparable. In conclusion, healthy non-obese men with a monophasic GRC have lower insulin clearance and muscle insulin sensitivity.
在 75 克口服葡萄糖耐量试验中，具有单相葡萄糖反应曲线（GRC）的个体比具有双相 GRC 的个体患 2 型糖尿病的风险更高。然而，尚无研究探讨 GRC 类型与胰岛素清除率之间的关系。因此，我们研究了 49 名健康的非肥胖日本男性。我们根据 GRC 的形状将研究参与者分为单相或双相组。我们使用两步高胰岛素-正常血糖钳夹技术评估组织特异性胰岛素敏感性和胰岛素清除率。单相组的内脏脂肪更多，胰岛素清除率和肌肉胰岛素敏感性更低，而肝和脂肪组织胰岛素敏感性和胰岛素分泌相当。总之，具有单相 GRC 的健康非肥胖男性的胰岛素清除率和肌肉胰岛素敏感性较低。
