Hong Jin Young, Kim Hyunseong, Lee Junseon, Jeon Wan-Jin, Yeo Changhwan, Kim Hyun, Lee Yoon Jae, Ha In-Hyuk
Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul 135-896, Republic of Korea.
Biomedicines. 2023 May 8;11(5):1390. doi: 10.3390/biomedicines11051390.
Epidural injection is one of the most common nonsurgical treatment options for long-term pain relief in lumbar spinal stenosis. Recently, various nerve block injections have been used for pain management. Among them, nerve block through epidural injection is a safe and effective method for the clinical treatment of low back or lower extremity pain. Although the epidural injection method has a long history, the effectiveness of long-term epidural injections in disc diseases has not been scientifically proven. In particular, to verify the safety and efficacy of drugs in preclinical studies, the route and method of drug administration in terms of the clinical application method and duration of use must be established. However, there is no standardized method for long-term epidural injections in a rat model of stenosis to identify the precise efficacy and safety of epidural injections. Therefore, standardizing the epidural injection method is very important for evaluating the efficacy and safety of drugs used for back or lower extremity pain. We describe the first standardized long-term epidural injection method for evaluating the efficacy and safety of drugs according to their route of administration in rats with lumbar spinal stenosis.
硬膜外注射是腰椎管狭窄症长期缓解疼痛最常见的非手术治疗选择之一。最近，各种神经阻滞注射已用于疼痛管理。其中，通过硬膜外注射进行神经阻滞是临床治疗腰背部或下肢疼痛的一种安全有效的方法。尽管硬膜外注射方法历史悠久，但长期硬膜外注射治疗椎间盘疾病的有效性尚未得到科学证实。特别是，为了在临床前研究中验证药物的安全性和有效性，必须根据临床应用方法和使用持续时间确定药物给药途径和方法。然而，在狭窄大鼠模型中，尚无用于确定硬膜外注射精确疗效和安全性的长期硬膜外注射标准化方法。因此，规范硬膜外注射方法对于评估用于腰背部或下肢疼痛的药物的疗效和安全性非常重要。我们描述了第一种标准化的长期硬膜外注射方法，用于根据给药途径评估腰椎管狭窄大鼠药物的疗效和安全性。
