Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul 135-896, Republic of Korea.
Cells. 2023 Sep 15;12(18):2281. doi: 10.3390/cells12182281.
Epidural administration is the leading therapeutic option for the management of pain associated with lumbar spinal stenosis (LSS), which is characterized by compression of the nerve root due to narrowing of the spinal canal. Corticosteroids are effective in alleviating LSS-related pain but can lead to complications with long-term use. Recent studies have focused on identifying promising medications administered epidurally to affected spinal regions. In this study, we aimed to investigate the effectiveness of harpagoside (HAS) as an epidural medication in rats with LSS. HAS at various concentrations was effective for neuroprotection against ferrous sulfate damage and consequent promotion of axonal outgrowth in primary spinal cord neurons. When two concentrations of HAS (100 and 200 μg/kg) were administered to the rat LSS model via the epidural space once a day for 4 weeks, the inflammatory responses around the silicone block used for LSS were substantially reduced. Consistently, pain-related factors were significantly suppressed by the epidural administration of HAS. The motor functions of rats with LSS significantly improved. These findings suggest that targeted delivery of HAS directly to the affected area via epidural injection holds promise as a potential treatment option for the recovery of patients with LSS.
硬膜外给药是治疗腰椎管狭窄症（LSS）相关疼痛的主要治疗选择，其特征是由于椎管狭窄导致神经根受压。皮质类固醇在缓解 LSS 相关疼痛方面有效，但长期使用会导致并发症。最近的研究集中在确定有希望的药物通过硬膜外途径施用于受影响的脊柱区域。在这项研究中，我们旨在研究哈巴俄苷（HAS）作为 LSS 大鼠硬膜外药物的有效性。不同浓度的 HAS 对硫酸亚铁损伤具有神经保护作用，并促进原代脊髓神经元轴突的生长。当 HAS 的两种浓度（100 和 200 μg/kg）通过硬膜外空间每天一次施用于大鼠 LSS 模型 4 周时，用于 LSS 的硅酮块周围的炎症反应显著减少。一致地，HAS 的硬膜外给药显著抑制了与疼痛相关的因素。LSS 大鼠的运动功能显著改善。这些发现表明，通过硬膜外注射将 HAS 直接靶向到受影响的区域具有作为 LSS 患者康复的潜在治疗选择的潜力。
