铝对基质诱导骨发育过程中矿化的影响。

Influence of aluminum on mineralization during matrix-induced bone development.

作者信息

Talwar H S, Reddi A H, Menczel J, Thomas W C, Meyer J L

出版信息

Kidney Int. 1986 May;29(5):1038-42. doi: 10.1038/ki.1986.104.

DOI:10.1038/ki.1986.104

Abstract

A model of de novo mineralization employing matrix-induced endochondral bone formation in rats was used to study the short-term effects of aluminum on the deposition of calcium and phosphate in vivo. In experiments where systemic aluminum concentrations were elevated, the cellular processes associated with bone development appeared to be normal, if somewhat delayed, however precipitation of the mineral phase was prevented. This suggests a primary direct physical chemical effect of aluminum in vivo on calcification, as suggested by in vitro studies which demonstrate that aluminum is a potent inhibitor of calcium phosphate precipitation. Aluminum salts implanted locally with the matrix appeared to be toxic to the cellular processes leading to chondrogenesis and osteogenesis.

摘要

采用基质诱导软骨内骨形成的大鼠新生矿化模型，研究铝对体内钙和磷沉积的短期影响。在全身铝浓度升高的实验中，与骨骼发育相关的细胞过程似乎正常，只是有所延迟，然而矿化相的沉淀被阻止了。这表明铝在体内对钙化有主要的直接物理化学作用，正如体外研究所表明的，铝是磷酸钙沉淀的有效抑制剂。局部与基质一起植入的铝盐似乎对导致软骨形成和骨形成的细胞过程有毒性。