Faculty of Physical Education, Gdansk University of Physical Education and Sport, K. Górskiego St. 1, 80-336 Gdansk, Poland.
Institute of Sports Sciences, The University of Physical Education in Krakow, 31-541 Kraków, Poland.
Int J Mol Sci. 2023 May 18;24(10):8931. doi: 10.3390/ijms24108931.
Human phenotypes (traits) are determined by the selective use of a person's unique genotype (DNA sequence), following exposure to environmental stimuli, such as exercise. Inducing profound changes in epigenetics may be an underlying factor of the beneficial effects of exercise. This study aimed to investigate the association between methylation in the promoter region of the gene and personality traits measured by the NEO-FFI questionnaire in a group of athletes. The study group included 163 athletes, and the control group consisted of 232 non-athletes. The obtained results show several significant differences between the studied groups of subjects. The Extraversion scale and the Conscientiousness scale results of the NEO-FFI are significantly higher in the group of athletes compared to controls. The total methylation and the number of methylated islands in the promoter region of the gene are higher in the study group. Pearson's linear correlation between the total methylation, the number of methylated islands and the NEO-FFI shows significant results for the Extraversion and Agreeability scales. The total methylation and the number of methylated islands in the promoter region of the gene are higher in the study group. Pearson's linear correlation between the total methylation, the number of methylated islands and the NEO-FFI shows significant results for the Extraversion and Agreeability scales. Our analysis of the methylation status of individual CpG sites revealed a new direction of research into the biological aspects of regulating dopamine release and personality traits in people practicing sports.
人类表型（特征）是由个体独特的基因型（DNA 序列）在暴露于环境刺激（如运动）后选择性使用决定的。表观遗传的深刻变化可能是运动有益效果的一个潜在因素。本研究旨在调查基因启动子区域甲基化与一组运动员的 NEO-FFI 问卷测量的人格特质之间的关联。研究组包括 163 名运动员，对照组包括 232 名非运动员。研究结果显示，两组研究对象之间存在几个显著差异。与对照组相比，NEO-FFI 的外向性和尽责性量表的结果在运动员组中明显更高。基因启动子区域的总甲基化和甲基化岛数量在研究组中更高。总甲基化、甲基化岛数量与 NEO-FFI 之间的 Pearson 线性相关性在外向性和宜人性量表上显示出显著结果。基因启动子区域的总甲基化和甲基化岛数量在研究组中更高。总甲基化、甲基化岛数量与 NEO-FFI 之间的 Pearson 线性相关性在外向性和宜人性量表上显示出显著结果。我们对个体 CpG 位点的甲基化状态的分析揭示了一个新的研究方向，即研究调节多巴胺释放和运动人群人格特质的生物学方面。
