慢性阻塞性肺疾病中的肺部和肠道微生物群
Lung and Gut Microbiome in COPD.
作者信息
Karakasidis Efstathios, Kotsiou Ourania S, Gourgoulianis Konstantinos I
机构信息
Department of Respiratory Medicine, School of Health Science, University of Thessaly, Biopolis, 41110 Larissa, Greece.
Department of Human Pathophysiology, Faculty of Nursing, School of Health Science, University of Thessaly, Gaiopolis, 41110 Larissa, Greece.
出版信息
J Pers Med. 2023 May 8;13(5):804. doi: 10.3390/jpm13050804.
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide. The association between lung and gut microbiomes in the pathogenesis of COPD has been recently uncovered. The goal of this study was to discuss the role of the lung and gut microbiomes in COPD pathophysiology. A systematic search of the PubMed database for relevant articles submitted up to June 2022 was performed. We examined the association between the lung and gut microbiome dysbiosis, reflected in bronchoalveolar lavage (BAL), lung tissue, sputum, and feces samples, and the pathogenesis and progression of COPD. It is evident that the lung and gut microbiomes affect each other and both play a vital role in the pathogenesis of COPD. However, more research needs to be carried out to find the exact associations between microbiome diversity and COPD pathophysiology and exacerbation genesis. Another field that research should focus on is the impact of treatment interventions targeting the human microbiome in preventing COPD genesis and progression.
慢性阻塞性肺疾病（COPD）是全球主要死因之一。近年来，肺部和肠道微生物群在COPD发病机制中的关联已被揭示。本研究的目的是探讨肺部和肠道微生物群在COPD病理生理学中的作用。我们对PubMed数据库进行了系统检索，以查找截至2022年6月提交的相关文章。我们研究了支气管肺泡灌洗（BAL）、肺组织、痰液和粪便样本中反映的肺部和肠道微生物群失调与COPD发病机制和进展之间的关联。显然，肺部和肠道微生物群相互影响，且在COPD发病机制中均起着至关重要的作用。然而，需要开展更多研究以找出微生物群多样性与COPD病理生理学及病情加重发生之间的确切关联。研究应关注的另一个领域是针对人类微生物群的治疗干预措施在预防COPD发生和进展方面的影响。
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