Danzi M, Ferulano G P, Abate S, Dilillo S, Califano G
J Surg Oncol. 1986 Apr;31(4):235-9. doi: 10.1002/jso.2930310403.
Records of 134 patients treated by abdomino-perineal resection (1971-1979) were reviewed. One hundred and thirteen had curative operations. Mortality was 2.6% and morbidity was 51%. Ninety-three were evaluable and were followed for 5 to 8 years; they were evaluated for survival and pattern of recurrence. Five-year survival for Dukes' A, B, C, and D lesions was 86, 62, 31, and 0%, respectively. Thirty-seven had recurrence: Four pelvic, nine pelvic and distant, and 24 only distant lesions. The overall incidence of failures was 47%, failure rates by stage were 11% for stage A, 27% for B, 48% for C, and 70% for D. Incidence of local recurrence was significantly higher in stage C compared to stage B. Irrespective of stage, after detection of local or distant recurrence, survival did not differ. Furthermore, radiotherapy for local recurrence and chemotherapy for distant lesions did not improve survival time.
回顾了1971年至1979年间接受腹会阴联合切除术治疗的134例患者的记录。其中113例接受了根治性手术。死亡率为2.6%，发病率为51%。93例可评估患者接受了5至8年的随访；对他们的生存情况和复发模式进行了评估。Dukes'A、B、C和D期病变的5年生存率分别为86%、62%、31%和0%。37例出现复发：4例为盆腔复发，9例为盆腔及远处复发，24例仅为远处病变。总体失败率为47%，各分期的失败率分别为：A期11%，B期27%，C期48%，D期70%。与B期相比，C期局部复发的发生率显著更高。无论分期如何，在检测到局部或远处复发后，生存率无差异。此外，局部复发的放疗和远处病变的化疗均未改善生存时间。
