Rosen L, Veidenheimer M C, Coller J A, Corman M L
Dis Colon Rectum. 1982 Apr;25(3):202-8. doi: 10.1007/BF02553101.
Records of 230 patients who underwent abdominoperineal resection between 1963 and 1976 were reviewed. The median age of the patients was 62 years. The mortality rate was 1.7 per cent, and the morbidity rate was 61 per cent. One hundred eighty patients were followed for five to 13 years to identify patterns of recurrence. Ten-year survival for Dukes' A, B, and C lesions was 83 per cent, 57 per cent, and 31 per cent, respectively. Seventy-eight patients (43 per cent) had recurrent cancer; 10 per cent had local lesions, and 33 per cent had distant lesions. Dukes' B lesions had a greater latency for local recurrence than Dukes' C lesions. Dukes' A lesions with distant recurrence had a greater latency than Dukes' B or C lesions. Once recurrence was established, the survival rate was not significantly different, regardless of Dukes' stage or local or distant site. Radiation therapy for established local recurrence or chemotherapy for established distant recurrence did not seem to alter survival rates.
回顾了1963年至1976年间接受腹会阴联合切除术的230例患者的记录。患者的中位年龄为62岁。死亡率为1.7%，发病率为61%。对180例患者进行了5至13年的随访，以确定复发模式。Dukes' A、B和C期病变的10年生存率分别为83%、57%和31%。78例患者（43%）发生了复发性癌症；10%为局部病变，33%为远处病变。Dukes' B期病变局部复发的潜伏期比Dukes' C期病变长。发生远处复发的Dukes' A期病变的潜伏期比Dukes' B期或C期病变长。一旦确定复发，无论Dukes'分期或局部或远处部位如何，生存率无显著差异。对于已确定的局部复发进行放射治疗或对于已确定的远处复发进行化疗似乎并未改变生存率。
