Jafari Mahtab, Schriner Samuel E, Kil Yun-Seo, Pham Sally T, Seo Eun Kyoung
Department of Pharmaceutical Sciences, University of California, Irvine, CA 92697, USA.
College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea.
Pharmaceuticals (Basel). 2023 May 12;16(5):738. doi: 10.3390/ph16050738.
is a perennial plant, belonging to the Apiaceae family and originating from Japan. This plant has been reported to act as a diuretic, analeptic, antidiabetic, hypertensive, tumor, galactagogue, and laxative. The mechanism of action of is not known, but previous studies have suggested that it may act as an antioxidant. In this work, we used to evaluate the impact of on lifespan and healthspan and its potential anti-aging mechanism by conducting multiple assays on three fly strains: , , and JIV. We observed that the extract extended lifespan and improved healthspan in a sex- and strain-dependent manner. extended lifespan and improved reproductive fitness in female flies and either had no effect or decreased survival and physical performance in males. The extract protected against the superoxide generator paraquat in both sexes. These sex-specific effects suggest that may act through age-specific pathways such as the insulin and insulin-like growth factor signaling (IIS) pathways. Upon examination, we found that the increased survival of -fed females was dependent on the presence of the insulin receptor substrate , supporting the role of IIS in the action of
是一种多年生植物，属于伞形科，原产于日本。据报道，这种植物具有利尿、兴奋、抗糖尿病、降血压、抗肿瘤、催乳和通便作用。其作用机制尚不清楚，但先前的研究表明它可能具有抗氧化作用。在这项工作中，我们通过对三种果蝇品系：、和JIV进行多项试验，使用来评估对寿命和健康寿命的影响及其潜在的抗衰老机制。我们观察到提取物以性别和品系依赖的方式延长了寿命并改善了健康寿命。提取物延长了雌性果蝇的寿命并提高了生殖适应性，而对雄性果蝇要么没有影响，要么降低了存活率和身体性能。该提取物在两性中都能抵御超氧化物产生剂百草枯。这些性别特异性效应表明可能通过特定年龄的途径发挥作用，如胰岛素和胰岛素样生长因子信号（IIS）途径。经检查，我们发现喂食的雌性果蝇存活率的提高依赖于胰岛素受体底物的存在，支持IIS在作用中的作用
