Prinz Julia, Maffulli Nicola, Fuest Matthias, Walter Peter, Hildebrand Frank, Migliorini Filippo
RWTH University Hospital of Aachen, 52074 Aachen, Germany.
Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Salerno, Italy.
Pharmaceuticals (Basel). 2023 May 18;16(5):762. doi: 10.3390/ph16050762.
This systematic review and meta-analysis investigated whether honey-related treatment strategies improve the signs and symptoms of patients with dry eye disease (DED). In March 2023, the following databases were accessed for clinical trials investigating the efficacy of honey-related treatment strategies in DED: PubMed, Web of Science, Google Scholar, and EMBASE. The following data were extracted at baseline and at the last follow-up: Ocular Surface Disease Index, tear breakup time, Schirmer I test, and corneal staining. Data from 323 patients were retrieved (53.3% female, mean age 40.6 ± 18.1 years). The mean follow-up was 7.0 ± 4.2 weeks. All the endpoints of interest significantly improved from baseline to the last follow-up: tear breakup time ( = 0.01), Ocular Surface Disease Index ( < 0.0001), Schirmer I test ( = 0.0001), and corneal staining ( < 0.0001). No difference was found in tear breakup time ( = 0.3), Ocular Surface Disease Index ( = 0.4), Schirmer I test ( = 0.3), and corneal staining ( = 0.3) between the honey-related treatment strategies and the control groups. According to our main results, honey-related treatment strategies are effective and feasible to improve symptoms and signs of DED.
本系统评价和荟萃分析调查了与蜂蜜相关的治疗策略是否能改善干眼症（DED）患者的体征和症状。2023年3月，检索了以下数据库以查找关于与蜂蜜相关的治疗策略在DED中疗效的临床试验：PubMed、科学网、谷歌学术和EMBASE。在基线和末次随访时提取了以下数据：眼表疾病指数、泪膜破裂时间、Schirmer I试验和角膜染色。检索到323例患者的数据（女性占53.3%，平均年龄40.6±18.1岁）。平均随访时间为7.0±4.2周。从基线到末次随访，所有感兴趣的终点指标均有显著改善：泪膜破裂时间（=0.01）、眼表疾病指数（<0.0001）、Schirmer I试验（=0.0001）和角膜染色（<0.0001）。与蜂蜜相关的治疗策略组和对照组在泪膜破裂时间（=0.3）、眼表疾病指数（=0.4）、Schirmer I试验（=0.3）和角膜染色（=0.3）方面未发现差异。根据我们的主要结果，与蜂蜜相关的治疗策略在改善DED的症状和体征方面是有效且可行的。
