Department of Bioengineering, Hanyang University, Seoul, South Korea.
Adv Drug Deliv Rev. 2009 Oct 5;61(12):1020-32. doi: 10.1016/j.addr.2009.07.006. Epub 2009 Jul 28.
Electrospinning techniques enable the production of continuous fibers with dimensions on the scale of nanometers from a wide range of natural and synthetic polymers. The number of recent studies regarding electrospun polysaccharides and their derivatives, which are potentially useful for regenerative medicine, is increasing dramatically. However, difficulties regarding the processibility of the polysaccharides (e.g., poor solubility and high surface tension) have limited their application. In this review, we summarize the characteristics of various polysaccharides such as alginate, cellulose, chitin, chitosan, hyaluronic acid, starch, dextran, and heparin, which are either currently being used or have potential to be used for electrospinning. The recent progress of nanofiber matrices electrospun from polysaccharides and their biomedical applications in tissue engineering, wound dressings, drug delivery, and enzyme immobilization are discussed.
静电纺丝技术能够从各种天然和合成聚合物中生产出具有纳米级尺寸的连续纤维。最近关于用于再生医学的电纺多糖及其衍生物的研究数量正在急剧增加。然而，多糖的加工性（例如，较差的溶解度和较高的表面张力）方面的困难限制了它们的应用。在这篇综述中，我们总结了各种多糖（例如藻酸盐、纤维素、壳聚糖、透明质酸、淀粉、葡聚糖和肝素）的特性，这些多糖目前正在被使用或有潜力被用于静电纺丝。讨论了由多糖电纺而成的纳米纤维基质的最新进展及其在组织工程、伤口敷料、药物输送和酶固定化中的生物医学应用。
