Department of Cell and Molecular Biology, Tulane University School of Science and Engineering, New Orleans, LA 70112, USA.
Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Viruses. 2023 Apr 28;15(5):1083. doi: 10.3390/v15051083.
Human cytomegalovirus (HCMV) exploits host mitochondrial function to promote viral replication. HCMV gene products have been described to directly interact and alter functional or structural aspects of host mitochondria. Current antivirals against HCMV, such as ganciclovir and letermovir, are designed against viral targets. Concerns with the current antivirals include toxicity and viral resistance. Targeting host mitochondrial function is a promising alternative or complimentary antiviral approach as (1) drugs targeting host mitochondrial function interact with host targets, minimizing viral resistance, and (2) host mitochondrial metabolism plays key roles in HCMV replication. This review describes how HCMV alters mitochondrial function and highlights pharmacological targets that can be exploited for novel antiviral development.
人巨细胞病毒（HCMV）利用宿主线粒体功能来促进病毒复制。已经描述了 HCMV 基因产物直接相互作用并改变宿主线粒体的功能或结构方面。目前针对 HCMV 的抗病毒药物，如更昔洛韦和乐韦迈，是针对病毒靶点设计的。目前抗病毒药物的问题包括毒性和病毒耐药性。针对宿主线粒体功能是一种有前途的替代或补充抗病毒方法，因为（1）针对宿主线粒体功能的药物与宿主靶标相互作用，最大限度地减少病毒耐药性，（2）宿主线粒体代谢在 HCMV 复制中发挥关键作用。本综述描述了 HCMV 如何改变线粒体功能，并强调了可用于新型抗病毒药物开发的药理学靶点。
