苍耳病毒 2 全基因组序列，一种从韩国苍耳中分离到的新型细胞弹状病毒。
Complete genome sequence of cnidium virus 2, a novel cytorhabdovirus isolated from Cnidium officinale in South Korea.
机构信息
Department of New Drug Discovery and Development, Chungnam National University, Daejeon, 34134, Republic of Korea.
NEXBIO Co., Ltd., Daejeon, 34520, Republic of Korea.
出版信息
Arch Virol. 2023 May 27;168(6):170. doi: 10.1007/s00705-023-05784-9.
High-throughput sequencing identified a cytorhabdovirus, tentatively named "cnidium virus 2" (CnV2), in Cnidium officinale, and Sanger sequencing confirmed the genome sequence. CnV2 is 13,527 nucleotides in length and contains seven open reading frames in the order 3'-N-P-3-4-M-G-L-5', separated by intergenic regions. The full-length nucleotide sequence of CnV2 shares 19.4-53.8% identity with other known cytorhabdovirus genome sequences. The N, P, P3, M, G, and L proteins share 15.8-66.7%, 11-64.3%, 11.1-80.5%, 10.8-75.3%, 12.3-72.1%, and 20-72.7% amino acid sequence identity, respectively, with the cognate deduced protein sequences from known cytorhabdoviruses. CnV2 is related to other members of the genus Cytorhabdovirus, with sambucus virus 1 being the closest relative. Thus, CnV2 should be classified as a new member in the genus Cytorhabdovirus of the family Rhabdoviridae.
高通量测序鉴定出一种细胞弹状病毒，暂命名为“茵陈病毒 2 型”（CnV2），存在于茵陈中，Sanger 测序证实了其基因组序列。CnV2 全长 13527 个核苷酸，包含 7 个开放阅读框，依次为 3'-N-P-3-4-M-G-L-5'，由基因间区隔开。CnV2 的全长核苷酸序列与其他已知细胞弹状病毒基因组序列的同源性为 19.4-53.8%。N、P、P3、M、G 和 L 蛋白分别与已知细胞弹状病毒的同源推定蛋白序列具有 15.8-66.7%、11-64.3%、11.1-80.5%、10.8-75.3%、12.3-72.1%和 20-72.7%的氨基酸序列同一性。CnV2 与该属的其他成员相关，与 sambucus 病毒 1 最为密切。因此，CnV2 应被分类为 Rhabdoviridae 科细胞弹状病毒属的一个新成员。
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