Central Research Laboratory, Institute of Medical Sciences and SUM Hospital, Siksha O Anusandhan Deemed to be University, Bhubaneswar, Odisha 751003, India.
Central Research Laboratory, Institute of Medical Sciences and SUM Hospital, Siksha O Anusandhan Deemed to be University, Bhubaneswar, Odisha 751003, India.
J Integr Med. 2023 Jul;21(4):332-353. doi: 10.1016/j.joim.2023.05.001. Epub 2023 May 8.
Acquired immune deficiency syndrome (AIDS) is a worldwide epidemic caused by human immunodeficiency virus (HIV) infection. Newer medicines for eliminating the viral reservoir and eradicating the virus are urgently needed. Attempts to locate relatively safe and non-toxic medications from natural resources are ongoing now. Natural-product-based antiviral candidates have been exploited to a limited extent. However, antiviral research is inadequate to counteract for the resistant patterns. Plant-derived bioactive compounds hold promise as powerful pharmacophore scaffolds, which have shown anti-HIV potential. This review focuses on a consideration of the virus, various possible HIV-controlling methods and the recent progress in alternative natural compounds with anti-HIV activity, with a particular emphasis on recent results from natural sources of anti-HIV agents. Please cite this article as: Mandhata CP, Sahoo CR, Padhy RN. A comprehensive overview on the role of phytocompounds in human immunodeficiency virus treatment. J Integr Med. 2023; 21(4):332-353.
获得性免疫缺陷综合征（AIDS）是由人类免疫缺陷病毒（HIV）感染引起的全球性流行病。目前迫切需要消除病毒储存库和根除病毒的新型药物。目前正在从自然资源中寻找相对安全和无毒的药物。已经在有限的程度上利用了基于天然产物的抗病毒候选药物。然而，抗病毒研究不足以对抗耐药模式。植物来源的生物活性化合物具有作为强大药效团支架的潜力，已显示出抗 HIV 潜力。本综述重点考虑了病毒、各种可能的 HIV 控制方法以及具有抗 HIV 活性的替代天然化合物的最新进展，特别强调了来自 HIV 抑制剂天然来源的最新结果。请引用本文为：Mandhata CP, Sahoo CR, Padhy RN. 植物化合物在人类免疫缺陷病毒治疗中的作用的综合概述。J 综合医学。2023;21(4):332-353。
