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理解精准肿瘤诊断中的不公平现象。

Understanding inequities in precision oncology diagnostics.

机构信息

Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Harvard Medical School, Boston, MA, USA.

出版信息

Nat Cancer. 2023 Jun;4(6):787-794. doi: 10.1038/s43018-023-00568-1. Epub 2023 May 29.

Abstract

Advances in molecular diagnostics have enabled the identification of targetable driver pathogenic variants, forming the basis of precision oncology care. However, the adoption of new technologies, such as next-generation sequencing (NGS) panels, can exacerbate healthcare disparities. Here, we summarize data on use patterns of advanced biomarker testing, highlight the disparities in both accessing NGS testing and using this data to match patients to appropriate personalized therapies and propose multidisciplinary strategies to address inequities looking forward.

摘要

分子诊断学的进步使得能够识别可靶向的驱动致病变体,从而为精准肿瘤学护理奠定了基础。然而,新技术的采用,如下一代测序(NGS)面板,可能会加剧医疗保健方面的差距。在这里,我们总结了先进生物标志物检测使用模式的数据,重点介绍了在获取 NGS 检测和使用这些数据将患者与合适的个性化治疗相匹配方面存在的差异,并提出了多学科策略来解决未来的不平等问题。

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