Jin Juan, Zhao Xiao-Xiao, Li Li, Fu Cai-Yun
Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2023 May;54(3):491-496. doi: 10.12182/20230560507.
Tumor microenvironment incorporates various tumor-related cellular and non-cellular components, playing a crucial role in the process of the pathogenesis, growth, and metastasis of tumors. Long noncoding RNA (lncRNA), a kind of noncoding RNA with a length of more than 200 nt, participates in a variety of physiological and pathological processes. Recent studies have shown that lncRNA plays a vital role in the interaction between tumors and the tumor microenvironment, thereby affecting tumor progression. Herein, we reviewed the research progress on the lncRNA in tumor microenvironment, discussed the potential application of lncRNA in early diagnosis and treatment of tumors, and suggested that some issues should be further explored in future research, including developing effective strategies for knocking out specific lncRNA and selecting appropriate delivery vehicles targeting specific cells.
肿瘤微环境包含各种与肿瘤相关的细胞和非细胞成分，在肿瘤的发病机制、生长和转移过程中起着至关重要的作用。长链非编码RNA（lncRNA）是一种长度超过200个核苷酸的非编码RNA，参与多种生理和病理过程。最近的研究表明，lncRNA在肿瘤与肿瘤微环境之间的相互作用中起着至关重要的作用，从而影响肿瘤进展。在此，我们综述了lncRNA在肿瘤微环境中的研究进展，讨论了lncRNA在肿瘤早期诊断和治疗中的潜在应用，并提出在未来研究中应进一步探索一些问题，包括开发敲除特定lncRNA的有效策略以及选择靶向特定细胞的合适递送载体。
