Key Lab for New Drug Research of TCM, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, Guangdong, China.
Department of Medical Oncology, Shenzhen People's Hospital (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of the Southern University of Science and Technology), Shenzhen 518020, China.
Biomater Sci. 2023 Jun 27;11(13):4727-4740. doi: 10.1039/d3bm00206c.
Many approaches have been employed to relieve hypoxia in solid tumors to enhance sensitivity to radiotherapy (RT), including O delivery or hydrogen peroxide (HO) decomposition strategies. To date, however, these modalities have been restricted by poor O loading, rapid O leakage, and limited endogenous HO levels. To overcome these limitations, we therefore sought to develop an effective approach for the oxygen-independent treatment of hypoxic tumors. In this study, we designed a novel black phosphorus quantum dot (BPQD)/ () hybrid system (BE) capable of facilitating the photothermal therapy (PTT) of hypoxic tumors. A simple electrostatic adsorption approach was used to conjugate BPQDs to . BE is capable of reliably targeting hypoxic tumors and mediating PTT. BPQDs in BE can directly facilitate X-ray-mediated radiosensitization of tumors, thereby achieving significant RT efficacy in response to lower doses of radiation, effectively and specifically damaging hypoxic tumor tissues to suppress the growth of tumors. Our results highlight this BE system as a novel approach to tumor radiosensitization with great potential for clinical application.
许多方法被用于缓解实体瘤的缺氧以提高放射治疗（RT）的敏感性，包括 O2 输送或过氧化氢（HO）分解策略。然而，迄今为止，这些方法受到 O2 负载不良、O2 快速泄漏和有限的内源性 HO 水平的限制。为了克服这些限制，因此我们寻求开发一种用于缺氧肿瘤的非氧依赖性治疗的有效方法。在这项研究中，我们设计了一种新型的黑磷量子点（BPQD）/（）杂化系统（BE），能够促进缺氧肿瘤的光热治疗（PTT）。通过简单的静电吸附方法将 BPQDs 偶联到上。BE 能够可靠地靶向缺氧肿瘤并介导 PTT。BE 中的 BPQDs 可以直接促进 X 射线介导的肿瘤放射增敏，从而在较低剂量的辐射下实现显著的 RT 疗效，有效地、特异性地损伤缺氧肿瘤组织，抑制肿瘤生长。我们的结果强调了这种 BE 系统作为一种具有临床应用潜力的肿瘤放射增敏的新方法。
