William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK.
Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.
Brain. 2023 Oct 3;146(10):4033-4039. doi: 10.1093/brain/awad182.
Melzak and Wall's gate control theory proposed that innocuous input into the dorsal horn of the spinal cord represses pain-inducing nociceptive input. Here we show that input from proprioceptive parvalbumin-expressing sensory neurons tonically represses nociceptor activation within dorsal root ganglia. Deletion of parvalbumin-positive sensory neurons leads to enhanced nociceptor activity measured with GCaMP3, increased input into wide dynamic range neurons of the spinal cord and increased acute and spontaneous pain behaviour, as well as potentiated innocuous sensation. Parvalbumin-positive sensory neurons express the enzymes and transporters necessary to produce vesicular GABA that is known to be released from depolarized somata. These observations support the view that gate control mechanisms occur peripherally within dorsal root ganglia.
梅尔扎克和沃尔的门控理论提出，无害的脊髓背角输入抑制引起疼痛的伤害性传入。在这里，我们表明，来自本体感觉表达 parvalbumin 的感觉神经元的输入持续抑制背根神经节中伤害感受器的激活。parvalbumin 阳性感觉神经元的缺失导致 GCaMP3 测量的伤害感受器活性增强，脊髓宽动态范围神经元的输入增加，急性和自发性疼痛行为增加，以及无害感觉增强。parvalbumin 阳性感觉神经元表达产生已知从去极化胞体释放的囊泡 GABA 的酶和转运体。这些观察结果支持门控机制发生在背根神经节的外围的观点。
